Comparison of18F-fluoride PET/CT, 18F-FDG PET/CT and bone scintigraphy (planar and SPECT) in detection of bone metastases of differentiated thyroid cancer: A pilot study

Naotoshi Ota, Katsuhiko Kato*, Shingo Iwano, Shinji Ito, Shinji Abe, Naotoshi Fujita, Keiichi Yamashiro, Seiichi Yamamoto, Shinji Naganawa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Objective: We compared the efficacies of 18F-fluoride positron emission tomography (18F-fluoride PET)/CT, 18F- fludeoxyglucose PET (18F-FDG PET)/CT, and 99mTc bone scintigraphy [planar and single photon emission CT (SPECT)] for the detection of bone metastases in patients with differentiated thyroid carcinoma (DTC). Methods: We examined 11 patients (8 females and 3 males; mean age ± standard deviation, 61.9 ± 8.7 years) with DTC who had been suspected of having bone metastases after total thyroidectomy and were hospitalized to be given 131I therapy. Bone metastases were verified either when positive findings were obtained on both 131I scintigraphy and CT or when MRI findings were positive if MRI was performed. Results: Metastases were confirmed in 24 (13.6%) of 176 bone segments in 9 (81.8%) of the 11 patients. The sensitivities of 18F-fluoride PET/CT and 99mTc bone scintigraphy (SPECT) were significantly higher than those of 18F-FDG PET/CT and 99mTc bone scintigraphy (planar) (p , 0.05). The accuracies of 18F- fluoride PET/CT and 99mTc bone scintigraphy (SPECT) were significantly higher than that of 99mTc bone scintigraphy (planar) ( p < 0.05). Conclusion: The sensitivity and accuracy of 18F-fluoride PET/CT for the detection of bone metastases of DTC are significantly higher than those of 99mTc bone scintigraphy (planar). However, the sensitivity and accuracy of 99mTc bone scintigraphy (planar) are improved near to those of 18F-fluoride PET/CT when SPECT is added to a planar scan. The sensitivity of 18F-FDG PET/CT is significantly lower than that of 18F-fluoride PET/CT or 99mTc bone scintigraphy (SPECT). Advances in knowledge: This article has demonstrated first the high efficacy of 18F-fluoride PET/CT for the detection of bone metastases of DTC.

Original languageEnglish
Article number20130444
JournalBritish Journal of Radiology
Volume87
Issue number1034
DOIs
Publication statusPublished - 2014 Feb 1
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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