Complete genome sequence of Finegoldia magna, an anaerobic opportunistic pathogen

Takatsugu Goto, Atsushi Yamashita, Hideki Hirakawa, Minenosuke Matsutani, Kozo Todo, Kenshiro Ohshima, Hidehiro Toh, Kazuaki Miyamoto, Satoru Kuhara, Masahira Hattori, Tohru Shimizu, Shigeru Akimoto

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Finegoldia magna (formerly Peptostreptococcus mtagnus), a member of the Gram-positive anaerobic cocci (GPAC), is a commensal bacterium colonizing human skin and mucous membranes. Moreover, it is also recognized as an opportunistic pathogen responsible for various infectious diseases. Here, we report the complete genome sequence of F. magna ATCC 29328. The genome consists of a 1 797 577 bp circular chromosome and an 189 163 bp plasmid (pPEP1). The metabolic maps constructed based on the genome information confirmed that most F. magna strains cannot ferment most sugars, except fructose, and have various aminopeptidase activities. Three homologs of albumin-binding protein, a known virulence factor useful for antiphagocytosis, are encoded on the chromosome, and one albumin-binding protein homolog is encoded on the plasmid. A unique feature of the genome is that F. magna encodes many sortase genes, of which substrates may be involved in bacterial pathogen-esis, such as antiphagocytosis and adherence to the host cell. The plasmid pPEP1 encodes seven sortase and seven substrate genes, whereas the chromosome encodes four sortase and 19 substrate genes. These plasmid-encoded sortases may play important roles in the pathogenesis of F. magna by enriching the variety of cell wall anchored surface proteins.

Original languageEnglish
Pages (from-to)39-47
Number of pages9
JournalDNA Research
Volume15
Issue number1
DOIs
Publication statusPublished - 2008
Externally publishedYes

Fingerprint

Plasmids
Genome
Chromosomes
Albumins
Carrier Proteins
Peptostreptococcus
Genes
Gram-Positive Cocci
Aminopeptidases
Virulence Factors
Fructose
Cell Wall
Communicable Diseases
Membrane Proteins
Mucous Membrane
Bacteria
Skin

Keywords

  • Albumin-binding protein
  • Gram-positive anaerobic cocci
  • Peptostreptococcus magnus
  • Sortase
  • Whole genome sequence

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Medicine(all)

Cite this

Goto, T., Yamashita, A., Hirakawa, H., Matsutani, M., Todo, K., Ohshima, K., ... Akimoto, S. (2008). Complete genome sequence of Finegoldia magna, an anaerobic opportunistic pathogen. DNA Research, 15(1), 39-47. https://doi.org/10.1093/dnares/dsm030

Complete genome sequence of Finegoldia magna, an anaerobic opportunistic pathogen. / Goto, Takatsugu; Yamashita, Atsushi; Hirakawa, Hideki; Matsutani, Minenosuke; Todo, Kozo; Ohshima, Kenshiro; Toh, Hidehiro; Miyamoto, Kazuaki; Kuhara, Satoru; Hattori, Masahira; Shimizu, Tohru; Akimoto, Shigeru.

In: DNA Research, Vol. 15, No. 1, 2008, p. 39-47.

Research output: Contribution to journalArticle

Goto, T, Yamashita, A, Hirakawa, H, Matsutani, M, Todo, K, Ohshima, K, Toh, H, Miyamoto, K, Kuhara, S, Hattori, M, Shimizu, T & Akimoto, S 2008, 'Complete genome sequence of Finegoldia magna, an anaerobic opportunistic pathogen', DNA Research, vol. 15, no. 1, pp. 39-47. https://doi.org/10.1093/dnares/dsm030
Goto T, Yamashita A, Hirakawa H, Matsutani M, Todo K, Ohshima K et al. Complete genome sequence of Finegoldia magna, an anaerobic opportunistic pathogen. DNA Research. 2008;15(1):39-47. https://doi.org/10.1093/dnares/dsm030
Goto, Takatsugu ; Yamashita, Atsushi ; Hirakawa, Hideki ; Matsutani, Minenosuke ; Todo, Kozo ; Ohshima, Kenshiro ; Toh, Hidehiro ; Miyamoto, Kazuaki ; Kuhara, Satoru ; Hattori, Masahira ; Shimizu, Tohru ; Akimoto, Shigeru. / Complete genome sequence of Finegoldia magna, an anaerobic opportunistic pathogen. In: DNA Research. 2008 ; Vol. 15, No. 1. pp. 39-47.
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