Complete nucleotide sequence of the IncN plasmid encoding imp-6 and CTX-M-2 from emerging carbapenem-resistant Enterobacteriaceae in japan

Shizuo Kayama, Norifumi Shigemoto, Ryuichi Kuwahara, Kenshiro Oshima, Hideki Hirakawa, Junzo Hisatsune, Thomas Jové, Hisaaki Nishio, Katsutoshi Yamasaki, Yasunao Wada, Takeshi Ueshimo, Tetsuya Miura, Taijiro Sueda, Makoto Onodera, Michiya Yokozaki, Masahira Hattori, Hiroki Ohge, Motoyuki Sugai

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We have determined the DNA sequence of Klebsiella pneumoniae multidrug resistance plasmid pKPI-6, which is a self-transmissible IncN-type plasmid. pKPI-6 harboring blaIMP-6 and blaCTX-M-2 confers a stealth-type carbapenem resistance phenotype on members of the family Enterobacteriaceae that is not detectable with imipenem. pKPI-6 is already epidemic in Japan, favoring the dissemination of IMP-6 and CTX-M-2 in members of the family Enterobacteriaceae.

Original languageEnglish
Pages (from-to)1356-1359
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume59
Issue number2
DOIs
Publication statusPublished - 2015 Feb 1
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

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  • Cite this

    Kayama, S., Shigemoto, N., Kuwahara, R., Oshima, K., Hirakawa, H., Hisatsune, J., Jové, T., Nishio, H., Yamasaki, K., Wada, Y., Ueshimo, T., Miura, T., Sueda, T., Onodera, M., Yokozaki, M., Hattori, M., Ohge, H., & Sugai, M. (2015). Complete nucleotide sequence of the IncN plasmid encoding imp-6 and CTX-M-2 from emerging carbapenem-resistant Enterobacteriaceae in japan. Antimicrobial Agents and Chemotherapy, 59(2), 1356-1359. https://doi.org/10.1128/AAC.04759