Complete structure elucidation of shishididemniols, complex lipids with tyramine-derived tether and two serinol units, from a marine tunicate of the family Didemnidae

Hirotsugu Kobayashi, Jun'ichiro Ohashi, Tsuyoshi Fujita, Takashi Iwashita, Yoichi Nakao, Shigeki Matsunaga, Nobuhiro Fusetani

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(Chemical Equation Presented) Two new serinolipid derivatives, shishididemniols A (1) and B (2), were isolated as antibacterial constituents of a tunicate of the family Didemnidae. The structure of 1 was elucidated by interpretation of spectral data and the application of the modified Mosher method to 1 and its suitable degradation products. Compound 2 was the chlorohydrin of 1. Compounds 1 and 2 exhibited antibacterial activity against fish pathogenic bacterium Vibrio anguillarum.

Original languageEnglish
Pages (from-to)1218-1225
Number of pages8
JournalJournal of Organic Chemistry
Issue number4
Publication statusPublished - 2007 Feb 16


ASJC Scopus subject areas

  • Organic Chemistry

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