Complete structure elucidation of shishididemniols, complex lipids with tyramine-derived tether and two serinol units, from a marine tunicate of the family Didemnidae

Hirotsugu Kobayashi, Jun'ichiro Ohashi, Tsuyoshi Fujita, Takashi Iwashita, Youichi Nakao, Shigeki Matsunaga, Nobuhiro Fusetani

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

(Chemical Equation Presented) Two new serinolipid derivatives, shishididemniols A (1) and B (2), were isolated as antibacterial constituents of a tunicate of the family Didemnidae. The structure of 1 was elucidated by interpretation of spectral data and the application of the modified Mosher method to 1 and its suitable degradation products. Compound 2 was the chlorohydrin of 1. Compounds 1 and 2 exhibited antibacterial activity against fish pathogenic bacterium Vibrio anguillarum.

Original languageEnglish
Pages (from-to)1218-1225
Number of pages8
JournalJournal of Organic Chemistry
Volume72
Issue number4
DOIs
Publication statusPublished - 2007 Feb 16
Externally publishedYes

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Chlorohydrins
Tyramine
Fish
Bacteria
Derivatives
Lipids
Degradation
shishididemniol A
serinol

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Complete structure elucidation of shishididemniols, complex lipids with tyramine-derived tether and two serinol units, from a marine tunicate of the family Didemnidae. / Kobayashi, Hirotsugu; Ohashi, Jun'ichiro; Fujita, Tsuyoshi; Iwashita, Takashi; Nakao, Youichi; Matsunaga, Shigeki; Fusetani, Nobuhiro.

In: Journal of Organic Chemistry, Vol. 72, No. 4, 16.02.2007, p. 1218-1225.

Research output: Contribution to journalArticle

Kobayashi, Hirotsugu ; Ohashi, Jun'ichiro ; Fujita, Tsuyoshi ; Iwashita, Takashi ; Nakao, Youichi ; Matsunaga, Shigeki ; Fusetani, Nobuhiro. / Complete structure elucidation of shishididemniols, complex lipids with tyramine-derived tether and two serinol units, from a marine tunicate of the family Didemnidae. In: Journal of Organic Chemistry. 2007 ; Vol. 72, No. 4. pp. 1218-1225.
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AU - Fusetani, Nobuhiro

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