Compression-induced changes on physical structures and calcification of the aromatic polyether polyurethane composite

Z. G. Tang, S. H. Teoh, W. McFarlane, L. Poole-Warren, Mitsuo Umezu

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    It is generally accepted that stress causes calcification in both bio-prosthetic and polyurethane heart valves. However, simple uni-axially- and bi-axially-stretched samples did not yield a feasible model for the elaboration of the stress-induced calcification. In this study, heat compaction combined with the incorporation of polyethylene has been explored. Specimens of polyurethane were solution cast onto a porous bi-axially-drawn ultra-high-molecular-weight polyethylene film and then heat compacted under a pressure of 18 MPa at a chosen temperature for 1.5 h. The heat-compaction-induced calcification and physical changes of the polyurethane composite were evaluated using a 28-day in vitro calcification model and Attenuated Total Reflection-Fourier Transform-Infrared (ATR-FT-IR) spectroscopy. The calcification results indicated that heat-compaction-induced calcification was double that achieved without heat compaction. Heat-compacted polyurethane composite showed higher affinity to calcium ions than the non-heat compacted sample. The ATR-FT-IR results showed that the heat-compaction-induced physical changes include distortions of polymeric molecules and permanent changes of microstructures. The distortions of polymeric molecules could be deteriorated in contact with different media. The relaxation of the stressed structures of the polyether moiety might serve as a calcium trap and a heterogeneous nucleation site for calcification. The permanent changes of microstructures resulted from high distortions also served as affinity sites attracting calcification.

    Original languageEnglish
    Pages (from-to)1117-1133
    Number of pages17
    JournalJournal of Biomaterials Science, Polymer Edition
    Volume14
    Issue number10
    DOIs
    Publication statusPublished - 2003

    Fingerprint

    Polyurethanes
    Polyethers
    Hot Temperature
    Compaction
    Composite materials
    Calcium
    Calcification (biochemistry)
    Microstructure
    Molecules
    Ultrahigh molecular weight polyethylenes
    Heart Valves
    Polyethylene
    Fourier Analysis
    Fourier Transform Infrared Spectroscopy
    Prosthetics
    Fourier transform infrared spectroscopy
    Polyethylenes
    Fourier transforms
    Nucleation
    Ions

    Keywords

    • ATR-FT-IR
    • Heat compaction
    • in vitro calcification
    • Physical structures
    • Polyurethane composite

    ASJC Scopus subject areas

    • Biophysics

    Cite this

    Compression-induced changes on physical structures and calcification of the aromatic polyether polyurethane composite. / Tang, Z. G.; Teoh, S. H.; McFarlane, W.; Poole-Warren, L.; Umezu, Mitsuo.

    In: Journal of Biomaterials Science, Polymer Edition, Vol. 14, No. 10, 2003, p. 1117-1133.

    Research output: Contribution to journalArticle

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