Computer modeling of cardiovascular fluid-structure interactions with the deforming-spatial-domain/stabilized space-time formulation

Ryo Torii, Marie Oshima, Toshio Kobayashi, Kiyoshi Takagi, Tayfun E. Tezduyar

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

Hemodynamic factors such as the wall shear stress are believed to affect a number of cardiovascular diseases including atherosclerosis and aneurysm. Since resolving phenomena in a living human body is currently beyond the capabilities of in vivo measurement techniques, computer modeling is expected to play an important role in gaining a better understanding of the relationship between the cardiovascular diseases and the hemodynamic factors. We have developed a computer modeling technique for cardiovascular hemodynamic simulations. With this modeling technique, patient-specific 3D geometry of an artery can be analyzed. We take into account some of the important factors in human body for the purpose of demonstrating in vivo situations in a virtual world. The interaction between the blood flow and the deformation of the arterial walls is a factor that we are specifically focusing on. For such fluid-structure interactions, we have developed a computer modeling tool based on the deforming-spatial-domain/stabilized space-time (DSD/SST) formulation. This simulation tool is applied to a patient-specific model under pulsatile blood flow conditions. The simulations show that the flow behavior with compliant arterial walls is different from what we see with rigid arterial walls. Consequently, the distribution of the wall shear stress on the compliant arterial walls is significantly different from that on the rigid arterial walls. We deduce that the compliance of the arterial walls needs to be taken into account in cardiovascular hemodynamic simulations, and the computer modeling tool we have developed can be effective in investigation of cardiovascular diseases.

Original languageEnglish
Pages (from-to)1885-1895
Number of pages11
JournalComputer Methods in Applied Mechanics and Engineering
Volume195
Issue number13-16
DOIs
Publication statusPublished - 2006 Feb 15
Externally publishedYes

Fingerprint

Fluid structure interaction
Hemodynamics
formulations
hemodynamics
fluids
Shear stress
Blood
interactions
human body
blood flow
shear stress
simulation
computer techniques
arteriosclerosis
Geometry
arteries
geometry

Keywords

  • Cardiovascular disease
  • DSD/SST method
  • Fluid-structure interaction

ASJC Scopus subject areas

  • Computational Mechanics
  • Mechanics of Materials
  • Mechanical Engineering
  • Physics and Astronomy(all)
  • Computer Science Applications

Cite this

Computer modeling of cardiovascular fluid-structure interactions with the deforming-spatial-domain/stabilized space-time formulation. / Torii, Ryo; Oshima, Marie; Kobayashi, Toshio; Takagi, Kiyoshi; Tezduyar, Tayfun E.

In: Computer Methods in Applied Mechanics and Engineering, Vol. 195, No. 13-16, 15.02.2006, p. 1885-1895.

Research output: Contribution to journalArticle

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