Concept of robotic gamma knife microradiosurgery and results of its clinical application in benign skull base tumors.

Motohiro Hayashi, Mikhail F. Chernov, Noriko Tamura, Masahiro Izawa, Yoshihiro Muragaki, Hiroshi Iseki, Yoshikazu Okada, Pavel Ivanov, Jean Régis, Kintomo Takakura

    Research output: Contribution to journalReview article

    6 Citations (Scopus)

    Abstract

    The availability of advanced computer-aided robotized devices for the Gamma Knife (i.e., an automatic positioning system and PerfeXion) resulted in significant changes in radiosurgical treatment strategy. The possibility of applying irradiation precisely and the significantly improved software for treatment planning led to the development of the original concept of robotic Gamma Knife microradiosurgery, which is comprised of the following: (1) precise irradiation of the lesion with regard to conformity and selectivity; (2) intentional avoidance of excessive irradiation of functionally important anatomical structures, particularly cranial nerves, located both within the target and in its vicinity; (3) delivery of sufficient radiation energy to the tumor with a goal of shrinking it while keeping the dose at the margins low enough to prevent complications. Realization of such treatment principles requires detailed evaluation of the microanatomy of the target area, which is achieved with an advanced neuroimaging protocol. From 2003, we applied the described microradiosurgical concept in our clinic for patients with benign skull base tumors. Overall, 75 % of neoplasms demonstrated shrinkage, and 47 % showed ≥50 % and more volume reduction. Treatment-related complications were encountered in only 6 % of patients and were mainly related to transient cranial nerve palsy. Just 2 % of neoplasms showed regrowth after irradiation. In conclusion, applying the microradiosurgical principles based on advanced neuroimaging and highly precise treatment planning is beneficial for patients, providing a high rate of tumor shrinkage and a low morbidity rate.

    Original languageEnglish
    Pages (from-to)5-15
    Number of pages11
    JournalUnknown Journal
    Volume116
    Publication statusPublished - 2013

    ASJC Scopus subject areas

    • Surgery
    • Clinical Neurology

    Fingerprint Dive into the research topics of 'Concept of robotic gamma knife microradiosurgery and results of its clinical application in benign skull base tumors.'. Together they form a unique fingerprint.

  • Cite this

    Hayashi, M., Chernov, M. F., Tamura, N., Izawa, M., Muragaki, Y., Iseki, H., Okada, Y., Ivanov, P., Régis, J., & Takakura, K. (2013). Concept of robotic gamma knife microradiosurgery and results of its clinical application in benign skull base tumors. Unknown Journal, 116, 5-15.