Concept of robotic gamma knife microradiosurgery and results of its clinical application in benign skull base tumors.

Motohiro Hayashi, Mikhail F. Chernov, Noriko Tamura, Masahiro Izawa, Yoshihiro Muragaki, Hiroshi Iseki, Yoshikazu Okada, Pavel Ivanov, Jean Régis, Kintomo Takakura

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The availability of advanced computer-aided robotized devices for the Gamma Knife (i.e., an automatic positioning system and PerfeXion) resulted in significant changes in radiosurgical treatment strategy. The possibility of applying irradiation precisely and the significantly improved software for treatment planning led to the development of the original concept of robotic Gamma Knife microradiosurgery, which is comprised of the following: (1) precise irradiation of the lesion with regard to conformity and selectivity; (2) intentional avoidance of excessive irradiation of functionally important anatomical structures, particularly cranial nerves, located both within the target and in its vicinity; (3) delivery of sufficient radiation energy to the tumor with a goal of shrinking it while keeping the dose at the margins low enough to prevent complications. Realization of such treatment principles requires detailed evaluation of the microanatomy of the target area, which is achieved with an advanced neuroimaging protocol. From 2003, we applied the described microradiosurgical concept in our clinic for patients with benign skull base tumors. Overall, 75 % of neoplasms demonstrated shrinkage, and 47 % showed ≥50 % and more volume reduction. Treatment-related complications were encountered in only 6 % of patients and were mainly related to transient cranial nerve palsy. Just 2 % of neoplasms showed regrowth after irradiation. In conclusion, applying the microradiosurgical principles based on advanced neuroimaging and highly precise treatment planning is beneficial for patients, providing a high rate of tumor shrinkage and a low morbidity rate.

Original languageEnglish
Pages (from-to)5-15
Number of pages11
JournalActa neurochirurgica. Supplement
Volume116
Publication statusPublished - 2013
Externally publishedYes

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Skull Base
Robotics
Neoplasms
Neuroimaging
Therapeutics
Cranial Nerve Diseases
Cranial Nerves
Software
Radiation
Morbidity
Equipment and Supplies

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Hayashi, M., Chernov, M. F., Tamura, N., Izawa, M., Muragaki, Y., Iseki, H., ... Takakura, K. (2013). Concept of robotic gamma knife microradiosurgery and results of its clinical application in benign skull base tumors. Acta neurochirurgica. Supplement, 116, 5-15.

Concept of robotic gamma knife microradiosurgery and results of its clinical application in benign skull base tumors. / Hayashi, Motohiro; Chernov, Mikhail F.; Tamura, Noriko; Izawa, Masahiro; Muragaki, Yoshihiro; Iseki, Hiroshi; Okada, Yoshikazu; Ivanov, Pavel; Régis, Jean; Takakura, Kintomo.

In: Acta neurochirurgica. Supplement, Vol. 116, 2013, p. 5-15.

Research output: Contribution to journalArticle

Hayashi, M, Chernov, MF, Tamura, N, Izawa, M, Muragaki, Y, Iseki, H, Okada, Y, Ivanov, P, Régis, J & Takakura, K 2013, 'Concept of robotic gamma knife microradiosurgery and results of its clinical application in benign skull base tumors.', Acta neurochirurgica. Supplement, vol. 116, pp. 5-15.
Hayashi, Motohiro ; Chernov, Mikhail F. ; Tamura, Noriko ; Izawa, Masahiro ; Muragaki, Yoshihiro ; Iseki, Hiroshi ; Okada, Yoshikazu ; Ivanov, Pavel ; Régis, Jean ; Takakura, Kintomo. / Concept of robotic gamma knife microradiosurgery and results of its clinical application in benign skull base tumors. In: Acta neurochirurgica. Supplement. 2013 ; Vol. 116. pp. 5-15.
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