Concise synthesis of 6-formylindolo[3,2-b]carbazole (FICZ)

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Abstract

A concise synthesis of 6-formylindolo[3,2-b]carbazole (FICZ), a potent ligand of the aryl hydrocarbon receptor (AhR), has been established. The conjugate addition of the enolate derived from indolylacetate 2 to 2-chloro-3-formylindole 3 was accomplished. The following cyclization reaction under the acidic conditions gave the indolo[3,2-b]carbazole skeleton.

Original languageEnglish
Pages (from-to)1932-1934
Number of pages3
JournalChemistry Letters
Volume43
Issue number12
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Chemistry(all)

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