Concise synthesis of reduced propionates by stereoselective reductions combined with the Kobayashi reaction

Tatsuya Nakamura, Mio Harachi, Takaaki Kano, Yuki Mukaeda, Seijiro Hosokawa

Research output: Contribution to journalArticle

15 Citations (Scopus)


A concise and straightforward synthesis of 2,4,6-trimethyloctanoates was established by using the sequence of the vinylogous Mukaiyama aldol reaction and regio- and stereoselective reduction reactions. All isomers were obtained selectively in a few steps. The short step synthesis of septoriamycin A, an antimalarial and antileishmanial agent, has been achieved by this methodology.

Original languageEnglish
Pages (from-to)3170-3173
Number of pages4
JournalOrganic Letters
Issue number12
Publication statusPublished - 2013 Jun 21


ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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