Concurrent blockade of β-adrenergic and muscarinic receptors suppresses synergistically long-term potentiation of population spikes in the rat hippocampal CA1 region

Masako Kobayashi, Masuo Ohno, Shigenobu Shibata, Tsuneyuki Yamamoto, Shigenori Watanabe

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The muscarinic acetylcholine receptor antagonist scopolamine, but not the β-adrenoceptor antagonist propranolol or atenolol, suppressed tetanus- induced long-term potentiation (LTP) of population spikes in the rat hippocampal CA1 region. When scopolamine was coapplied with propranolol or atenolol, a synergistic effect in preventing LTP generation was observed. On the other hand, the coapplication of scopolamine and atenolol failed to affect tetanus-induced LTP of field EPSP. These findings suggest that cooperative mechanisms via muscarnic and β-adrenergic receptor activation might contribute to LTP induction in terms of the EPSP-spike potentiation, i.e., an increase in the excitability of hippocampal CA1 pyramidal cells after tetanic stimulation, but are independent of the tetanus-evoked potentiation of a suynaptic component.

Original languageEnglish
Pages (from-to)242-246
Number of pages5
JournalBrain Research
Volume777
Issue number1-2
DOIs
Publication statusPublished - 1997 Nov 28

Keywords

  • Acetylcholine
  • Hippocampus
  • Long-term potentiation
  • Muscarinic receptor
  • Noradrenaline
  • β-Adrenoceptor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Concurrent blockade of β-adrenergic and muscarinic receptors suppresses synergistically long-term potentiation of population spikes in the rat hippocampal CA1 region'. Together they form a unique fingerprint.

  • Cite this