Concurrent blockade of β-adrenergic and muscarinic receptors suppresses synergistically long-term potentiation of population spikes in the rat hippocampal CA1 region

Masako Kobayashi, Masuo Ohno, Shigenobu Shibata, Tsuneyuki Yamamoto, Shigenori Watanabe

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Abstract

    The muscarinic acetylcholine receptor antagonist scopolamine, but not the β-adrenoceptor antagonist propranolol or atenolol, suppressed tetanus- induced long-term potentiation (LTP) of population spikes in the rat hippocampal CA1 region. When scopolamine was coapplied with propranolol or atenolol, a synergistic effect in preventing LTP generation was observed. On the other hand, the coapplication of scopolamine and atenolol failed to affect tetanus-induced LTP of field EPSP. These findings suggest that cooperative mechanisms via muscarnic and β-adrenergic receptor activation might contribute to LTP induction in terms of the EPSP-spike potentiation, i.e., an increase in the excitability of hippocampal CA1 pyramidal cells after tetanic stimulation, but are independent of the tetanus-evoked potentiation of a suynaptic component.

    Original languageEnglish
    Pages (from-to)242-246
    Number of pages5
    JournalBrain Research
    Volume777
    Issue number1-2
    DOIs
    Publication statusPublished - 1997 Nov 28

    Fingerprint

    Hippocampal CA1 Region
    Long-Term Potentiation
    Muscarinic Receptors
    Adrenergic Receptors
    Atenolol
    Scopolamine Hydrobromide
    Tetanus
    Excitatory Postsynaptic Potentials
    Propranolol
    Population
    Pyramidal Cells
    Cholinergic Antagonists

    Keywords

    • β-Adrenoceptor
    • Acetylcholine
    • Hippocampus
    • Long-term potentiation
    • Muscarinic receptor
    • Noradrenaline

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Concurrent blockade of β-adrenergic and muscarinic receptors suppresses synergistically long-term potentiation of population spikes in the rat hippocampal CA1 region. / Kobayashi, Masako; Ohno, Masuo; Shibata, Shigenobu; Yamamoto, Tsuneyuki; Watanabe, Shigenori.

    In: Brain Research, Vol. 777, No. 1-2, 28.11.1997, p. 242-246.

    Research output: Contribution to journalArticle

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