Conditioned social preference, but not place preference, produced by intranasal oxytocin in female mice

Yutaka Kosaki, Shigeru Watanabe

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Oxytocin (OT) has been implicated in a variety of mammalian reproductive and social behaviors, and the use of intranasal OT for clinical purposes is on the rise. However, basic actions of OT, including the rewarding or reinforcing properties of the drug, are currently not fully understood. In this study, the authors investigated whether intranasally administered OT has different reinforcing properties for social and nonsocial stimuli and whether such effects are variable between male and female subjects. Conditioned social preference (CSP) and conditioned place preference (CPP) paradigms were used to examine social and nonsocial reinforcing properties of OT. In CSP, the presence of a same-sex unfamiliar conspecific was repeatedly paired with intranasal OT, while a different conspecific was associated with saline. The reinforcing effect of OT was assessed in a postconditioning choice test under a drug-free condition. In CPP, the 2 conspecifics were replaced with nonsocial black and white compartments. The authors found that intranasal OT (12 μg) in females supported the formation of CSP (Experiment 1) but not CPP (Experiment 3). Neither CSP (Experiment 2) nor CPP (Experiment 4) was formed in males. Extended conditioning with higher dose OT (36 μg), however, abolished the initial CSP in females and produced an aversion to the OT-paired stimulus mouse. Experiment 5 indicated that it was the repeated administrations rather than the higher dose that produced the abolition of the original preference. Overall, the current results demonstrate for the first time a sex- and stimulus-dependent reinforcing property of intranasal OT in mice.

Original languageEnglish
Pages (from-to)182-195
Number of pages14
JournalBehavioral Neuroscience
Volume130
Issue number2
DOIs
Publication statusPublished - 2016 Apr 1
Externally publishedYes

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Oxytocin
Reproductive Behavior
Social Behavior
Pharmaceutical Preparations

Keywords

  • Intranasal administration
  • Mice
  • Oxytocin
  • Reinforcing property
  • Selective association
  • Sex difference
  • Social preference

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Conditioned social preference, but not place preference, produced by intranasal oxytocin in female mice. / Kosaki, Yutaka; Watanabe, Shigeru.

In: Behavioral Neuroscience, Vol. 130, No. 2, 01.04.2016, p. 182-195.

Research output: Contribution to journalArticle

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