Construction and analysis of a human-chimpanzee comparative clone map

Asao Fujiyama; Hidemi Watanabe; Atsushi Toyoda; Todd D. Taylor; Takehiko Itoh; Shih Feng Tsai; Hong Seog Park; Marie Laure Yaspo; Hans Lehrach; Zhu Chen; Gang Fu; Naruya Saitou; Kazutoyo Osoegawa; Pieter J. De Jong; Yumiko Suto; Masahira Hattori; Yoshiyuki Sakaki

doi:10.1126/science.1065199

Construction and analysis of a human-chimpanzee comparative clone map

Asao Fujiyama^*, Hidemi Watanabe, Atsushi Toyoda, Todd D. Taylor, Takehiko Itoh, Shih Feng Tsai, Hong Seog Park, Marie Laure Yaspo, Hans Lehrach, Zhu Chen, Gang Fu, Naruya Saitou, Kazutoyo Osoegawa, Pieter J. De Jong, Yumiko Suto, Masahira Hattori, Yoshiyuki Sakaki

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

201 Citations (Scopus)

Abstract

The recently released human genome sequences provide us with reference data to conduct comparative genomic research on primates, which will be important to understand what genetic information makes us human. Here we present a first-generation human-chimpanzee comparative genome map and its initial analysis. The map was constructed through paired alignment of 77,461 chimpanzee bacterial artificial chromosome end sequences with publicly available human genome sequences. We detected candidate positions, including two clusters on human chromosome 21 that suggest large, nonrandom regions of difference between the two genomes.

Original language	English
Pages (from-to)	131-134
Number of pages	4
Journal	Science
Volume	295
Issue number	5552
DOIs	https://doi.org/10.1126/science.1065199
Publication status	Published - 2002 Jan 4
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1126/science.1065199

Cite this

@article{b93f863ec7b8447385feb2e3c7f4e5f9,

title = "Construction and analysis of a human-chimpanzee comparative clone map",

abstract = "The recently released human genome sequences provide us with reference data to conduct comparative genomic research on primates, which will be important to understand what genetic information makes us human. Here we present a first-generation human-chimpanzee comparative genome map and its initial analysis. The map was constructed through paired alignment of 77,461 chimpanzee bacterial artificial chromosome end sequences with publicly available human genome sequences. We detected candidate positions, including two clusters on human chromosome 21 that suggest large, nonrandom regions of difference between the two genomes.",

author = "Asao Fujiyama and Hidemi Watanabe and Atsushi Toyoda and Taylor, {Todd D.} and Takehiko Itoh and Tsai, {Shih Feng} and Park, {Hong Seog} and Yaspo, {Marie Laure} and Hans Lehrach and Zhu Chen and Gang Fu and Naruya Saitou and Kazutoyo Osoegawa and {De Jong}, {Pieter J.} and Yumiko Suto and Masahira Hattori and Yoshiyuki Sakaki",

year = "2002",

month = jan,

day = "4",

doi = "10.1126/science.1065199",

language = "English",

volume = "295",

pages = "131--134",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5552",

}

TY - JOUR

T1 - Construction and analysis of a human-chimpanzee comparative clone map

AU - Fujiyama, Asao

AU - Watanabe, Hidemi

AU - Toyoda, Atsushi

AU - Taylor, Todd D.

AU - Itoh, Takehiko

AU - Tsai, Shih Feng

AU - Park, Hong Seog

AU - Yaspo, Marie Laure

AU - Lehrach, Hans

AU - Chen, Zhu

AU - Fu, Gang

AU - Saitou, Naruya

AU - Osoegawa, Kazutoyo

AU - De Jong, Pieter J.

AU - Suto, Yumiko

AU - Hattori, Masahira

AU - Sakaki, Yoshiyuki

PY - 2002/1/4

Y1 - 2002/1/4

N2 - The recently released human genome sequences provide us with reference data to conduct comparative genomic research on primates, which will be important to understand what genetic information makes us human. Here we present a first-generation human-chimpanzee comparative genome map and its initial analysis. The map was constructed through paired alignment of 77,461 chimpanzee bacterial artificial chromosome end sequences with publicly available human genome sequences. We detected candidate positions, including two clusters on human chromosome 21 that suggest large, nonrandom regions of difference between the two genomes.

AB - The recently released human genome sequences provide us with reference data to conduct comparative genomic research on primates, which will be important to understand what genetic information makes us human. Here we present a first-generation human-chimpanzee comparative genome map and its initial analysis. The map was constructed through paired alignment of 77,461 chimpanzee bacterial artificial chromosome end sequences with publicly available human genome sequences. We detected candidate positions, including two clusters on human chromosome 21 that suggest large, nonrandom regions of difference between the two genomes.

UR - http://www.scopus.com/inward/record.url?scp=0037016456&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037016456&partnerID=8YFLogxK

U2 - 10.1126/science.1065199

DO - 10.1126/science.1065199

M3 - Article

C2 - 11778049

AN - SCOPUS:0037016456

SN - 0036-8075

VL - 295

SP - 131

EP - 134

JO - Science

JF - Science

IS - 5552

ER -

Construction and analysis of a human-chimpanzee comparative clone map

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this