Construction and analysis of a human-chimpanzee comparative clone map

Asao Fujiyama, Hidemi Watanabe, Atsushi Toyoda, Todd D. Taylor, Takehiko Itoh, Shih Feng Tsai, Hong Seog Park, Marie Laure Yaspo, Hans Lehrach, Zhu Chen, Gang Fu, Naruya Saitou, Kazutoyo Osoegawa, Pieter J. De Jong, Yumiko Suto, Masahira Hattori, Yoshiyuki Sakaki

Research output: Contribution to journalArticle

182 Citations (Scopus)

Abstract

The recently released human genome sequences provide us with reference data to conduct comparative genomic research on primates, which will be important to understand what genetic information makes us human. Here we present a first-generation human-chimpanzee comparative genome map and its initial analysis. The map was constructed through paired alignment of 77,461 chimpanzee bacterial artificial chromosome end sequences with publicly available human genome sequences. We detected candidate positions, including two clusters on human chromosome 21 that suggest large, nonrandom regions of difference between the two genomes.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalScience
Volume295
Issue number5552
DOIs
Publication statusPublished - 2002 Jan 4
Externally publishedYes

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Pan troglodytes
Human Genome
Clone Cells
Genome
Bacterial Artificial Chromosomes
Chromosomes, Human, Pair 21
Human Chromosomes
Primates
Research

ASJC Scopus subject areas

  • General

Cite this

Fujiyama, A., Watanabe, H., Toyoda, A., Taylor, T. D., Itoh, T., Tsai, S. F., ... Sakaki, Y. (2002). Construction and analysis of a human-chimpanzee comparative clone map. Science, 295(5552), 131-134. https://doi.org/10.1126/science.1065199

Construction and analysis of a human-chimpanzee comparative clone map. / Fujiyama, Asao; Watanabe, Hidemi; Toyoda, Atsushi; Taylor, Todd D.; Itoh, Takehiko; Tsai, Shih Feng; Park, Hong Seog; Yaspo, Marie Laure; Lehrach, Hans; Chen, Zhu; Fu, Gang; Saitou, Naruya; Osoegawa, Kazutoyo; De Jong, Pieter J.; Suto, Yumiko; Hattori, Masahira; Sakaki, Yoshiyuki.

In: Science, Vol. 295, No. 5552, 04.01.2002, p. 131-134.

Research output: Contribution to journalArticle

Fujiyama, A, Watanabe, H, Toyoda, A, Taylor, TD, Itoh, T, Tsai, SF, Park, HS, Yaspo, ML, Lehrach, H, Chen, Z, Fu, G, Saitou, N, Osoegawa, K, De Jong, PJ, Suto, Y, Hattori, M & Sakaki, Y 2002, 'Construction and analysis of a human-chimpanzee comparative clone map', Science, vol. 295, no. 5552, pp. 131-134. https://doi.org/10.1126/science.1065199
Fujiyama A, Watanabe H, Toyoda A, Taylor TD, Itoh T, Tsai SF et al. Construction and analysis of a human-chimpanzee comparative clone map. Science. 2002 Jan 4;295(5552):131-134. https://doi.org/10.1126/science.1065199
Fujiyama, Asao ; Watanabe, Hidemi ; Toyoda, Atsushi ; Taylor, Todd D. ; Itoh, Takehiko ; Tsai, Shih Feng ; Park, Hong Seog ; Yaspo, Marie Laure ; Lehrach, Hans ; Chen, Zhu ; Fu, Gang ; Saitou, Naruya ; Osoegawa, Kazutoyo ; De Jong, Pieter J. ; Suto, Yumiko ; Hattori, Masahira ; Sakaki, Yoshiyuki. / Construction and analysis of a human-chimpanzee comparative clone map. In: Science. 2002 ; Vol. 295, No. 5552. pp. 131-134.
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