Construction and analysis of a human-chimpanzee comparative clone map

Asao Fujiyama, Hidemi Watanabe, Atsushi Toyoda, Todd D. Taylor, Takehiko Itoh, Shih Feng Tsai, Hong Seog Park, Marie Laure Yaspo, Hans Lehrach, Zhu Chen, Gang Fu, Naruya Saitou, Kazutoyo Osoegawa, Pieter J. De Jong, Yumiko Suto, Masahira Hattori, Yoshiyuki Sakaki

Research output: Contribution to journalArticle

184 Citations (Scopus)

Abstract

The recently released human genome sequences provide us with reference data to conduct comparative genomic research on primates, which will be important to understand what genetic information makes us human. Here we present a first-generation human-chimpanzee comparative genome map and its initial analysis. The map was constructed through paired alignment of 77,461 chimpanzee bacterial artificial chromosome end sequences with publicly available human genome sequences. We detected candidate positions, including two clusters on human chromosome 21 that suggest large, nonrandom regions of difference between the two genomes.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalScience
Volume295
Issue number5552
DOIs
Publication statusPublished - 2002 Jan 4
Externally publishedYes

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    Fujiyama, A., Watanabe, H., Toyoda, A., Taylor, T. D., Itoh, T., Tsai, S. F., Park, H. S., Yaspo, M. L., Lehrach, H., Chen, Z., Fu, G., Saitou, N., Osoegawa, K., De Jong, P. J., Suto, Y., Hattori, M., & Sakaki, Y. (2002). Construction and analysis of a human-chimpanzee comparative clone map. Science, 295(5552), 131-134. https://doi.org/10.1126/science.1065199