Continuous generation of femtolitre droplets using multistage dividing microfluidic channel

Kentaro Kawai; Masaru Fujii; Junichi Uchikoshi; Kenta Arima; Shuichi Shoji; Mizuho Morita

doi:10.1016/j.cap.2012.06.022

Continuous generation of femtolitre droplets using multistage dividing microfluidic channel

Kentaro Kawai, Masaru Fujii, Junichi Uchikoshi, Kenta Arima, Shuichi Shoji, Mizuho Morita

School of Fundamental Science and Engineering

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We describe a novel method for generation of femtolitre-order monodisperse droplets using a multistage dividing microfluidic channel. A droplet is uniformly divided into 16 parts in a four-stage microfluidic channel without the need for external equipment. The droplets become smaller as the cross-junction part becomes narrower (range from 87.8 to 9.05 pL). Central micropillar structures at each bifurcation reduce the difference in the channel resistance throughout the microchannel between two side-channel that is divided by micropillar structures, which enables the equivalent division of femtolitre-order-volume droplets. After the fourth bifurcation, the minimum radius of a daughter droplet is 5 μm (ca. 524 fL) and the coefficient variation is 0.51%. The generation rate is 3800 droplets/s in a single-droplet generation line.

Original language	English
Pages (from-to)	S33-S37
Journal	Current Applied Physics
Volume	12
Issue number	SUPPL.3
DOIs	https://doi.org/10.1016/j.cap.2012.06.022
Publication status	Published - 2012 Dec

Keywords

Droplet
Femtolitre droplet
Microfluidics
Multistage division

ASJC Scopus subject areas

Materials Science(all)
Physics and Astronomy(all)

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title = "Continuous generation of femtolitre droplets using multistage dividing microfluidic channel",

abstract = "We describe a novel method for generation of femtolitre-order monodisperse droplets using a multistage dividing microfluidic channel. A droplet is uniformly divided into 16 parts in a four-stage microfluidic channel without the need for external equipment. The droplets become smaller as the cross-junction part becomes narrower (range from 87.8 to 9.05 pL). Central micropillar structures at each bifurcation reduce the difference in the channel resistance throughout the microchannel between two side-channel that is divided by micropillar structures, which enables the equivalent division of femtolitre-order-volume droplets. After the fourth bifurcation, the minimum radius of a daughter droplet is 5 μm (ca. 524 fL) and the coefficient variation is 0.51%. The generation rate is 3800 droplets/s in a single-droplet generation line.",

keywords = "Droplet, Femtolitre droplet, Microfluidics, Multistage division",

author = "Kentaro Kawai and Masaru Fujii and Junichi Uchikoshi and Kenta Arima and Shuichi Shoji and Mizuho Morita",

note = "Funding Information: This work was partly supported by a Grant-in-Aid for Science Basic Research (A) (No. 19206046 ) from the Ministry of Education, Culture, Sports Science and Technology of Japan , the Super COE ASMeW , and the Global COE of Waseda University .",

year = "2012",

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doi = "10.1016/j.cap.2012.06.022",

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AU - Kawai, Kentaro

AU - Fujii, Masaru

AU - Uchikoshi, Junichi

AU - Arima, Kenta

AU - Shoji, Shuichi

AU - Morita, Mizuho

N1 - Funding Information: This work was partly supported by a Grant-in-Aid for Science Basic Research (A) (No. 19206046 ) from the Ministry of Education, Culture, Sports Science and Technology of Japan , the Super COE ASMeW , and the Global COE of Waseda University .

PY - 2012/12

Y1 - 2012/12

N2 - We describe a novel method for generation of femtolitre-order monodisperse droplets using a multistage dividing microfluidic channel. A droplet is uniformly divided into 16 parts in a four-stage microfluidic channel without the need for external equipment. The droplets become smaller as the cross-junction part becomes narrower (range from 87.8 to 9.05 pL). Central micropillar structures at each bifurcation reduce the difference in the channel resistance throughout the microchannel between two side-channel that is divided by micropillar structures, which enables the equivalent division of femtolitre-order-volume droplets. After the fourth bifurcation, the minimum radius of a daughter droplet is 5 μm (ca. 524 fL) and the coefficient variation is 0.51%. The generation rate is 3800 droplets/s in a single-droplet generation line.

AB - We describe a novel method for generation of femtolitre-order monodisperse droplets using a multistage dividing microfluidic channel. A droplet is uniformly divided into 16 parts in a four-stage microfluidic channel without the need for external equipment. The droplets become smaller as the cross-junction part becomes narrower (range from 87.8 to 9.05 pL). Central micropillar structures at each bifurcation reduce the difference in the channel resistance throughout the microchannel between two side-channel that is divided by micropillar structures, which enables the equivalent division of femtolitre-order-volume droplets. After the fourth bifurcation, the minimum radius of a daughter droplet is 5 μm (ca. 524 fL) and the coefficient variation is 0.51%. The generation rate is 3800 droplets/s in a single-droplet generation line.

KW - Droplet

KW - Femtolitre droplet

KW - Microfluidics

KW - Multistage division

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Continuous generation of femtolitre droplets using multistage dividing microfluidic channel

Abstract

Keywords

ASJC Scopus subject areas

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