Continuous generation of femtolitre droplets using multistage dividing microfluidic channel

Kentaro Kawai*, Masaru Fujii, Junichi Uchikoshi, Kenta Arima, Shuichi Shoji, Mizuho Morita

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


We describe a novel method for generation of femtolitre-order monodisperse droplets using a multistage dividing microfluidic channel. A droplet is uniformly divided into 16 parts in a four-stage microfluidic channel without the need for external equipment. The droplets become smaller as the cross-junction part becomes narrower (range from 87.8 to 9.05 pL). Central micropillar structures at each bifurcation reduce the difference in the channel resistance throughout the microchannel between two side-channel that is divided by micropillar structures, which enables the equivalent division of femtolitre-order-volume droplets. After the fourth bifurcation, the minimum radius of a daughter droplet is 5 μm (ca. 524 fL) and the coefficient variation is 0.51%. The generation rate is 3800 droplets/s in a single-droplet generation line.

Original languageEnglish
Pages (from-to)S33-S37
JournalCurrent Applied Physics
Issue numberSUPPL.3
Publication statusPublished - 2012 Dec


  • Droplet
  • Femtolitre droplet
  • Microfluidics
  • Multistage division

ASJC Scopus subject areas

  • Materials Science(all)
  • Physics and Astronomy(all)


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