Control of circadian activity of birds by the interaction of melatonin with 7α-hydroxypregnenolone, a newly discovered neurosteroid stimulating locomotion

Kazuyoshi Tsutsui, Shogo Haraguchi, Kazuhiko Inoue, Hitomi Miyabara, Saori Suzuki, Takayoshi Ubuka

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    Melatonin regulates diurnal locomotor rhythms in birds as well as in other vertebrates, but the molecular mechanism by which melatonin regulates locomotor activity is poorly understood. Here, we summarize new findings showing that 7α-hydroxypregnenolone, a previously undescribed avian neurosteroid, mediates melatonin action on diurnal locomotor rhythms in birds. Recently, 7α-hydroxypregnenolone was identified as a novel avian neurosteroid in Japanese quail Coturnix japonica brain. It was found that 7α-hydroxypregnenolone acutely stimulates quail locomotor activity. Subsequently, it was clarified that diurnal changes in 7α-hydroxypregnenolone synthesis occur in parallel with changes in locomotor activity in quail. Finally, it was demonstrated that melatonin depresses the synthesis of 7α-hydroxypregnenolone, thus providing a mechanism through which the nocturnal increase in melatonin regulates diurnal changes in locomotor activity. This review highlights a novel molecular mechanism controlling circadian activity of birds by the interaction of melatonin with 7α-hydroxypregnenolone, a newly discovered neurosteroid stimulating locomotion.

    Original languageEnglish
    Pages (from-to)235-243
    Number of pages9
    JournalJournal of Ornithology
    Volume153
    Issue numberSUPPL. 1
    DOIs
    Publication statusPublished - 2012 Aug

    Fingerprint

    melatonin
    locomotion
    birds
    quails
    synthesis
    vertebrates
    brain

    Keywords

    • 7α-hydroxypregnenolone
    • Cytochrome P450
    • Diurnal changes
    • Dopamine
    • Locomotor activity
    • Neurosteroids
    • Quail

    ASJC Scopus subject areas

    • Animal Science and Zoology

    Cite this

    Control of circadian activity of birds by the interaction of melatonin with 7α-hydroxypregnenolone, a newly discovered neurosteroid stimulating locomotion. / Tsutsui, Kazuyoshi; Haraguchi, Shogo; Inoue, Kazuhiko; Miyabara, Hitomi; Suzuki, Saori; Ubuka, Takayoshi.

    In: Journal of Ornithology, Vol. 153, No. SUPPL. 1, 08.2012, p. 235-243.

    Research output: Contribution to journalArticle

    Tsutsui, Kazuyoshi ; Haraguchi, Shogo ; Inoue, Kazuhiko ; Miyabara, Hitomi ; Suzuki, Saori ; Ubuka, Takayoshi. / Control of circadian activity of birds by the interaction of melatonin with 7α-hydroxypregnenolone, a newly discovered neurosteroid stimulating locomotion. In: Journal of Ornithology. 2012 ; Vol. 153, No. SUPPL. 1. pp. 235-243.
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