Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances

Kohei Kubota, Hideo Kanazawa, Shuji Hisamoto, Shinji Takeoka

Research output: Contribution to conferencePaper

Abstract

Liposomes of which the surface was modified with poly(ethylene glycol) (PEG) chains are used to prevent aggregation and fusion and to prolong blood circulation. PEG-lipids were immobilized onto the surface of liposomes by simply adding their aqueous dispersions to the liposome dispersions. However, they dissociated from the liposomes by dilution of the mixed dispersions because they were incorporated into the liposomes in an equilibrium state. For the tight immobilization of the PEG-lipids with the long PEG chain onto the liposome surface, an increased number of alkyl chains is necessary.

Original languageEnglish
Number of pages1
Publication statusPublished - 2005 Dec 1
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: 2005 May 252005 May 27

Conference

Conference54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period05/5/2505/5/27

Keywords

  • Hydrophilic-hydrophobic balance
  • Liposome
  • Multi alkyl chains
  • Poly(ethylene glycol)-lipid

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Kubota, K., Kanazawa, H., Hisamoto, S., & Takeoka, S. (2005). Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.