Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances

Kohei Kubota, Hideo Kanazawa, Shuji Hisamoto, Shinji Takeoka

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Liposomes of which the surface was modified with poly(ethylene glycol) (PEG) chains are used to prevent aggregation and fusion and to prolong blood circulation. PEG-lipids were immobilized onto the surface of liposomes by simply adding their aqueous dispersions to the liposome dispersions. However, they dissociated from the liposomes by dilution of the mixed dispersions because they were incorporated into the liposomes in an equilibrium state. For the tight immobilization of the PEG-lipids with the long PEG chain onto the liposome surface, an increased number of alkyl chains is necessary.

    Original languageEnglish
    Title of host publicationPolymer Preprints, Japan
    Pages2132
    Number of pages1
    Volume54
    Edition1
    Publication statusPublished - 2005
    Event54th SPSJ Annual Meeting 2005 - Yokohama
    Duration: 2005 May 252005 May 27

    Other

    Other54th SPSJ Annual Meeting 2005
    CityYokohama
    Period05/5/2505/5/27

    Fingerprint

    Liposomes
    Lipids
    Polyethylene glycols
    Surface treatment
    Dispersions
    Hemodynamics
    Dilution
    Fusion reactions
    Agglomeration

    Keywords

    • Hydrophilic-hydrophobic balance
    • Liposome
    • Multi alkyl chains
    • Poly(ethylene glycol)-lipid

    ASJC Scopus subject areas

    • Engineering(all)

    Cite this

    Kubota, K., Kanazawa, H., Hisamoto, S., & Takeoka, S. (2005). Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances. In Polymer Preprints, Japan (1 ed., Vol. 54, pp. 2132)

    Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances. / Kubota, Kohei; Kanazawa, Hideo; Hisamoto, Shuji; Takeoka, Shinji.

    Polymer Preprints, Japan. Vol. 54 1. ed. 2005. p. 2132.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Kubota, K, Kanazawa, H, Hisamoto, S & Takeoka, S 2005, Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances. in Polymer Preprints, Japan. 1 edn, vol. 54, pp. 2132, 54th SPSJ Annual Meeting 2005, Yokohama, 05/5/25.
    Kubota K, Kanazawa H, Hisamoto S, Takeoka S. Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances. In Polymer Preprints, Japan. 1 ed. Vol. 54. 2005. p. 2132
    Kubota, Kohei ; Kanazawa, Hideo ; Hisamoto, Shuji ; Takeoka, Shinji. / Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances. Polymer Preprints, Japan. Vol. 54 1. ed. 2005. pp. 2132
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