Control theoretic views on circadian rhythms

T. Takeuchi, T. Hinohara, Kenko Uchida, Shigenobu Shibata

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)

    Abstract

    Circadian rhythms, which are observed in most of living things, e.g. bacteria, fungi, plants, and animals, are self-sustained oscillations with about 24 hours period, and have the following properties: The first property is that the oscillation is entrained by light/dark cycles; the second one is that the oscillation, especially the period of the oscillation, is robust against changes of environment. In this paper, we investigate these two properties from control theoretic viewpoints. First, considering light/dark cycle as periodic control input, we try to explain how periodic control inputs can entrain one self-sustained circadian oscillator described by a core molecular model for Drosophila by Goldbeter (1995). Second, for structural understanding of robustness of circadian rhythms, we propose an evaluation method of the robustness based on period sensitivity, and try to design some rate parameters, which are regarded as control parameters, based on some optimizations using a robustness measure, when a rate parameter is moved to outside of normal area by environmental changes.

    Original languageEnglish
    Title of host publicationProceedings of the IEEE International Conference on Control Applications
    Pages1740-1745
    Number of pages6
    DOIs
    Publication statusPublished - 2006
    Event2006 IEEE International Conference on Control Applications, CCA 2006 - Munich
    Duration: 2006 Oct 42006 Oct 6

    Other

    Other2006 IEEE International Conference on Control Applications, CCA 2006
    CityMunich
    Period06/10/406/10/6

    Fingerprint

    Circadian Rhythm
    Oscillation
    Robustness
    Cycle
    Drosophilidae
    Evaluation Method
    Fungi
    Bacteria
    Control Parameter
    Thing
    Animals
    Optimization

    ASJC Scopus subject areas

    • Control and Systems Engineering
    • Computer Science Applications
    • Mathematics(all)

    Cite this

    Takeuchi, T., Hinohara, T., Uchida, K., & Shibata, S. (2006). Control theoretic views on circadian rhythms. In Proceedings of the IEEE International Conference on Control Applications (pp. 1740-1745). [4776904] https://doi.org/10.1109/CACSD-CCA-ISIC.2006.4776904

    Control theoretic views on circadian rhythms. / Takeuchi, T.; Hinohara, T.; Uchida, Kenko; Shibata, Shigenobu.

    Proceedings of the IEEE International Conference on Control Applications. 2006. p. 1740-1745 4776904.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Takeuchi, T, Hinohara, T, Uchida, K & Shibata, S 2006, Control theoretic views on circadian rhythms. in Proceedings of the IEEE International Conference on Control Applications., 4776904, pp. 1740-1745, 2006 IEEE International Conference on Control Applications, CCA 2006, Munich, 06/10/4. https://doi.org/10.1109/CACSD-CCA-ISIC.2006.4776904
    Takeuchi T, Hinohara T, Uchida K, Shibata S. Control theoretic views on circadian rhythms. In Proceedings of the IEEE International Conference on Control Applications. 2006. p. 1740-1745. 4776904 https://doi.org/10.1109/CACSD-CCA-ISIC.2006.4776904
    Takeuchi, T. ; Hinohara, T. ; Uchida, Kenko ; Shibata, Shigenobu. / Control theoretic views on circadian rhythms. Proceedings of the IEEE International Conference on Control Applications. 2006. pp. 1740-1745
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