Control theoretic views on circadian rhythms

T. Takeuchi, T. Hinohara, Kenko Uchida, Shigenobu Shibata

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    2 Citations (Scopus)

    Abstract

    Circadian rhythms, which are observed in most of living things, e.g. bacteria, fungi, plants, and animals, are self-sustained oscillations with about 24 hours period, and have the following properties: The first property is that the oscillation is entrained by light/dark cycles; the second one is that the oscillation, especially the period of the oscillation, is robust against changes of environment. In this paper, we investigate these two properties from control theoretic viewpoints. First, considering light/dark cycle as periodic control input, we try to explain how periodic control inputs can entrain one self-sustained circadian oscillator described by a core molecular model for Drosophila by Goldbeter (1995). Second, for structural understanding of robustness of circadian rhythms, we propose an evaluation method of the robustness based on period sensitivity, and try to design some rate parameters, which are regarded as control parameters, based on some optimizations using a robustness measure, when a rate parameter is moved to outside of normal area by environmental changes.

    Original languageEnglish
    Title of host publicationProceedings of the IEEE International Conference on Control Applications
    Pages1740-1745
    Number of pages6
    DOIs
    Publication statusPublished - 2007
    EventJoint 2006 IEEE Conference on Control Applications (CCA), Computer-Aided Control Systems Design Symposium (CACSD) and International Symposium on Intelligent Control (ISIC) - Munich
    Duration: 2006 Oct 42006 Oct 6

    Other

    OtherJoint 2006 IEEE Conference on Control Applications (CCA), Computer-Aided Control Systems Design Symposium (CACSD) and International Symposium on Intelligent Control (ISIC)
    CityMunich
    Period06/10/406/10/6

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    ASJC Scopus subject areas

    • Engineering(all)

    Cite this

    Takeuchi, T., Hinohara, T., Uchida, K., & Shibata, S. (2007). Control theoretic views on circadian rhythms. In Proceedings of the IEEE International Conference on Control Applications (pp. 1740-1745). [4067419] https://doi.org/10.1109/CCA.2006.286136