Abstract
Free feeding (FF) with a high fat diet (HFD) causes excessive body weight gain, whereas restricted feeding (RF) with a HFD attenuates body weight gain. The effects of timing of feeding with a HFD (day vs. night) and feeding duration on energy homeostasis have not yet been investigated. In this study, we fed mice a HFD or a normal diet (ND) twice a day, during their active and inactive periods, on a schedule. The amount of food was regulated by feeding duration (2, 4 or 8h). First, we investigated the effects of 4-h RF during active-inactive periods (ND-ND, HFD-HFD, ND-HFD or HFD-ND). Among all the 4-h RF groups, mice consumed almost the same amount of calories as those in the FF[ND] group, even those fed a HFD. Body weight and visceral fat in these three groups were lower than that in the FF[HFD] group. Second, we investigated the effects of RF duration. Body weight and visceral fat were higher in the 8-h groups than in the 4-h groups. Body weight and visceral fat were higher in the 2-h groups than in the 4-h groups even though the 2-h groups had less food. Third, we investigated the effects of eating a HFD during the inactive period, when RF duration was extended (2, 6 or 12h). Mice were fed with a HFD during the inactive period for 2h and fed with a ND during the active period for 2, 6 or 12h. Body weight and visceral fat in these mice were comparable to those in the FF[ND] mice. The results of our first set of experiments suggest that 4-h RF was an adequate feeding duration to control the effect of a HFD on obesity. The results of our second set of experiments suggest 2-h RF (such as speed-eating) and 8-h RF, representative of eating disorders, are unhealthy feeding patterns related to obesity. The results of our third set of experiments suggest that eating a HFD for a short period during the night does not affect body weight and visceral fat. Taken together, these results indicate that consideration to feeding with a HFD during the inactive period and restricting eating habits relieve the risks of body weight gain and visceral fat accumulation.
| Original language | English |
|---|---|
| Pages (from-to) | 935-944 |
| Number of pages | 10 |
| Journal | Chronobiology International |
| Volume | 31 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2014 Oct 1 |
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Keywords
- Circadian rhythm
- High fat diet
- Liver
- Night eating
- Period
- Phase
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
Cite this
Controlling access time to a high-fat diet during the inactive period protects against obesity in mice. / Haraguchi, Atsushi; Aoki, Natsumi; Ohtsu, Teiji; Ikeda, Yuko; Tahara, Yu; Shibata, Shigenobu.
In: Chronobiology International, Vol. 31, No. 8, 01.10.2014, p. 935-944.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Controlling access time to a high-fat diet during the inactive period protects against obesity in mice
AU - Haraguchi, Atsushi
AU - Aoki, Natsumi
AU - Ohtsu, Teiji
AU - Ikeda, Yuko
AU - Tahara, Yu
AU - Shibata, Shigenobu
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Free feeding (FF) with a high fat diet (HFD) causes excessive body weight gain, whereas restricted feeding (RF) with a HFD attenuates body weight gain. The effects of timing of feeding with a HFD (day vs. night) and feeding duration on energy homeostasis have not yet been investigated. In this study, we fed mice a HFD or a normal diet (ND) twice a day, during their active and inactive periods, on a schedule. The amount of food was regulated by feeding duration (2, 4 or 8h). First, we investigated the effects of 4-h RF during active-inactive periods (ND-ND, HFD-HFD, ND-HFD or HFD-ND). Among all the 4-h RF groups, mice consumed almost the same amount of calories as those in the FF[ND] group, even those fed a HFD. Body weight and visceral fat in these three groups were lower than that in the FF[HFD] group. Second, we investigated the effects of RF duration. Body weight and visceral fat were higher in the 8-h groups than in the 4-h groups. Body weight and visceral fat were higher in the 2-h groups than in the 4-h groups even though the 2-h groups had less food. Third, we investigated the effects of eating a HFD during the inactive period, when RF duration was extended (2, 6 or 12h). Mice were fed with a HFD during the inactive period for 2h and fed with a ND during the active period for 2, 6 or 12h. Body weight and visceral fat in these mice were comparable to those in the FF[ND] mice. The results of our first set of experiments suggest that 4-h RF was an adequate feeding duration to control the effect of a HFD on obesity. The results of our second set of experiments suggest 2-h RF (such as speed-eating) and 8-h RF, representative of eating disorders, are unhealthy feeding patterns related to obesity. The results of our third set of experiments suggest that eating a HFD for a short period during the night does not affect body weight and visceral fat. Taken together, these results indicate that consideration to feeding with a HFD during the inactive period and restricting eating habits relieve the risks of body weight gain and visceral fat accumulation.
AB - Free feeding (FF) with a high fat diet (HFD) causes excessive body weight gain, whereas restricted feeding (RF) with a HFD attenuates body weight gain. The effects of timing of feeding with a HFD (day vs. night) and feeding duration on energy homeostasis have not yet been investigated. In this study, we fed mice a HFD or a normal diet (ND) twice a day, during their active and inactive periods, on a schedule. The amount of food was regulated by feeding duration (2, 4 or 8h). First, we investigated the effects of 4-h RF during active-inactive periods (ND-ND, HFD-HFD, ND-HFD or HFD-ND). Among all the 4-h RF groups, mice consumed almost the same amount of calories as those in the FF[ND] group, even those fed a HFD. Body weight and visceral fat in these three groups were lower than that in the FF[HFD] group. Second, we investigated the effects of RF duration. Body weight and visceral fat were higher in the 8-h groups than in the 4-h groups. Body weight and visceral fat were higher in the 2-h groups than in the 4-h groups even though the 2-h groups had less food. Third, we investigated the effects of eating a HFD during the inactive period, when RF duration was extended (2, 6 or 12h). Mice were fed with a HFD during the inactive period for 2h and fed with a ND during the active period for 2, 6 or 12h. Body weight and visceral fat in these mice were comparable to those in the FF[ND] mice. The results of our first set of experiments suggest that 4-h RF was an adequate feeding duration to control the effect of a HFD on obesity. The results of our second set of experiments suggest 2-h RF (such as speed-eating) and 8-h RF, representative of eating disorders, are unhealthy feeding patterns related to obesity. The results of our third set of experiments suggest that eating a HFD for a short period during the night does not affect body weight and visceral fat. Taken together, these results indicate that consideration to feeding with a HFD during the inactive period and restricting eating habits relieve the risks of body weight gain and visceral fat accumulation.
KW - Circadian rhythm
KW - High fat diet
KW - Liver
KW - Night eating
KW - Period
KW - Phase
UR - http://www.scopus.com/inward/record.url?scp=84907043492&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907043492&partnerID=8YFLogxK
U2 - 10.3109/07420528.2014.931413
DO - 10.3109/07420528.2014.931413
M3 - Article
C2 - 24984029
AN - SCOPUS:84907043492
VL - 31
SP - 935
EP - 944
JO - Annual Review of Chronopharmacology
JF - Annual Review of Chronopharmacology
SN - 0743-9539
IS - 8
ER -