Abstract
Reaction of phenols in dimethyl carbonate in the presence of cesium carbonate at 120-160° C gave aryl methyl ethers in good yields, whereas the reaction of aliphatic alcohols gave the corresponding alkyl carbonates. This method provides a useful synthetic method for preparation of various aryl methyl ethers without using toxic methyl iodide or dimethyl sulfate. O-Methylation of the aromatic hydroxy group of estradiol was carried out in 2 steps without protection of the alcoholic hydroxy group in the same molecule.
| Original language | English |
|---|---|
| Pages (from-to) | 1063-1064 |
| Number of pages | 2 |
| Journal | Synlett |
| Issue number | 10 |
| Publication status | Published - 1998 Oct |
Fingerprint
ASJC Scopus subject areas
- Organic Chemistry
Cite this
Convenient O-methylation of phenols with dimethyl carbonate. / Lee, Youngmin; Shimizu, Isao.
In: Synlett, No. 10, 10.1998, p. 1063-1064.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Convenient O-methylation of phenols with dimethyl carbonate
AU - Lee, Youngmin
AU - Shimizu, Isao
PY - 1998/10
Y1 - 1998/10
N2 - Reaction of phenols in dimethyl carbonate in the presence of cesium carbonate at 120-160° C gave aryl methyl ethers in good yields, whereas the reaction of aliphatic alcohols gave the corresponding alkyl carbonates. This method provides a useful synthetic method for preparation of various aryl methyl ethers without using toxic methyl iodide or dimethyl sulfate. O-Methylation of the aromatic hydroxy group of estradiol was carried out in 2 steps without protection of the alcoholic hydroxy group in the same molecule.
AB - Reaction of phenols in dimethyl carbonate in the presence of cesium carbonate at 120-160° C gave aryl methyl ethers in good yields, whereas the reaction of aliphatic alcohols gave the corresponding alkyl carbonates. This method provides a useful synthetic method for preparation of various aryl methyl ethers without using toxic methyl iodide or dimethyl sulfate. O-Methylation of the aromatic hydroxy group of estradiol was carried out in 2 steps without protection of the alcoholic hydroxy group in the same molecule.
UR - http://www.scopus.com/inward/record.url?scp=27844598336&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27844598336&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:27844598336
SP - 1063
EP - 1064
JO - Synlett
JF - Synlett
SN - 0936-5214
IS - 10
ER -