Convenient O-methylation of phenols with dimethyl carbonate

Youngmin Lee, Isao Shimizu

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Reaction of phenols in dimethyl carbonate in the presence of cesium carbonate at 120-160° C gave aryl methyl ethers in good yields, whereas the reaction of aliphatic alcohols gave the corresponding alkyl carbonates. This method provides a useful synthetic method for preparation of various aryl methyl ethers without using toxic methyl iodide or dimethyl sulfate. O-Methylation of the aromatic hydroxy group of estradiol was carried out in 2 steps without protection of the alcoholic hydroxy group in the same molecule.

Original languageEnglish
Pages (from-to)1063-1064
Number of pages2
JournalSynlett
Issue number10
Publication statusPublished - 1998 Oct

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Methyl Ethers
Methylation
Phenols
Poisons
Carbonates
Estradiol
Alcohols
Molecules
methyl carbonate
cesium carbonate
methyl iodide
dimethyl sulfate

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Lee, Y., & Shimizu, I. (1998). Convenient O-methylation of phenols with dimethyl carbonate. Synlett, (10), 1063-1064.

Convenient O-methylation of phenols with dimethyl carbonate. / Lee, Youngmin; Shimizu, Isao.

In: Synlett, No. 10, 10.1998, p. 1063-1064.

Research output: Contribution to journalArticle

Lee, Y & Shimizu, I 1998, 'Convenient O-methylation of phenols with dimethyl carbonate', Synlett, no. 10, pp. 1063-1064.
Lee Y, Shimizu I. Convenient O-methylation of phenols with dimethyl carbonate. Synlett. 1998 Oct;(10):1063-1064.
Lee, Youngmin ; Shimizu, Isao. / Convenient O-methylation of phenols with dimethyl carbonate. In: Synlett. 1998 ; No. 10. pp. 1063-1064.
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