Convenient O-methylation of phenols with dimethyl carbonate

Youngmin Lee, Isao Shimizu

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Reaction of phenols in dimethyl carbonate in the presence of cesium carbonate at 120-160° C gave aryl methyl ethers in good yields, whereas the reaction of aliphatic alcohols gave the corresponding alkyl carbonates. This method provides a useful synthetic method for preparation of various aryl methyl ethers without using toxic methyl iodide or dimethyl sulfate. O-Methylation of the aromatic hydroxy group of estradiol was carried out in 2 steps without protection of the alcoholic hydroxy group in the same molecule.

Original languageEnglish
Pages (from-to)1063-1064
Number of pages2
JournalSynlett
Issue number10
Publication statusPublished - 1998 Oct

ASJC Scopus subject areas

  • Organic Chemistry

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  • Cite this

    Lee, Y., & Shimizu, I. (1998). Convenient O-methylation of phenols with dimethyl carbonate. Synlett, (10), 1063-1064.