Convergent total synthesis of (+)-ophiobolin A

Kazuhiro Tsuna, Naoyoshi Noguchi, Masahisa Nakada*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


At long last: The enantioselective total synthesis of the title compound, which was isolated in 1958, proceeds by a convergent approach. The assembly of the C,D-ring fragment and the A-ring fragment of the core structure is achieved by employing a Reformatsky-type reaction. The eight-membered carbocyclic B ring is efficiently constructed by a challenging ring-closing metathesis (see scheme).

Original languageEnglish
Pages (from-to)9452-9455
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number40
Publication statusPublished - 2011 Sept 26


  • cross-coupling
  • natural products
  • ring-closing metathesis
  • sesterterpenes
  • total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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