At long last: The enantioselective total synthesis of the title compound, which was isolated in 1958, proceeds by a convergent approach. The assembly of the C,D-ring fragment and the A-ring fragment of the core structure is achieved by employing a Reformatsky-type reaction. The eight-membered carbocyclic B ring is efficiently constructed by a challenging ring-closing metathesis (see scheme).
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 2011 Sept 26|
- natural products
- ring-closing metathesis
- total synthesis
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