TY - JOUR
T1 - Coronary arterial dynamics computation with medical-image-based time-dependent anatomical models and element-based zero-stress state estimates
AU - Takizawa, Kenji
AU - Torii, Ryo
AU - Takagi, Hirokazu
AU - Tezduyar, Tayfun E.
AU - Xu, Xiao Y.
N1 - Funding Information:
This work was supported in part by the Rice–Waseda research agreement and also in part by JST-CREST (first and third authors). The authors are grateful to Dr. Jennifer Keegan and Professor David Firmin (CMR Unit, Royal Brompton Hospital and Imperial College, London) for the acquisition of the MRI images, and also to Drs. Katherine March and Chloe Park (International Centre for Circulatory Health) for their help in acquiring the pressure profile.
Publisher Copyright:
© 2014, The Author(s).
PY - 2014/10/1
Y1 - 2014/10/1
N2 - We propose a method for coronary arterial dynamics computation with medical-image-based time-dependent anatomical models. The objective is to improve the computational analysis of coronary arteries for better understanding of the links between the atherosclerosis development and mechanical stimuli such as endothelial wall shear stress and structural stress in the arterial wall. The method has two components. The first one is element-based zero-stress (ZS) state estimation, which is an alternative to prestress calculation. The second one is a “mixed ZS state” approach, where the ZS states for different elements in the structural mechanics mesh are estimated with reference configurations based on medical images coming from different instants within the cardiac cycle. We demonstrate the robustness of the method in a patient-specific coronary arterial dynamics computation where the motion of a thin strip along the arterial surface and two cut surfaces at the arterial ends is specified to match the motion extracted from the medical images.
AB - We propose a method for coronary arterial dynamics computation with medical-image-based time-dependent anatomical models. The objective is to improve the computational analysis of coronary arteries for better understanding of the links between the atherosclerosis development and mechanical stimuli such as endothelial wall shear stress and structural stress in the arterial wall. The method has two components. The first one is element-based zero-stress (ZS) state estimation, which is an alternative to prestress calculation. The second one is a “mixed ZS state” approach, where the ZS states for different elements in the structural mechanics mesh are estimated with reference configurations based on medical images coming from different instants within the cardiac cycle. We demonstrate the robustness of the method in a patient-specific coronary arterial dynamics computation where the motion of a thin strip along the arterial surface and two cut surfaces at the arterial ends is specified to match the motion extracted from the medical images.
KW - Coronary arterial dynamics
KW - Coronary atherosclerosis
KW - Element-based zero-stress state estimate
KW - Medical-image-based data
KW - Mixed zero-stress state
KW - Time-dependent anatomical model
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U2 - 10.1007/s00466-014-1049-6
DO - 10.1007/s00466-014-1049-6
M3 - Article
AN - SCOPUS:84920260543
VL - 54
SP - 1047
EP - 1053
JO - Computational Mechanics
JF - Computational Mechanics
SN - 0178-7675
IS - 4
ER -