Coupling of a cardiovascular model with a thermoregulation model to predict human blood pressure under unsteady environmental conditions

Yoshito Takahashi, Masayuki Oata, Asaka Jun-Ichi, Akihisa Nomoto, Shinichi Tanabe

Research output: Contribution to journalConference article


We coupled a cardiovascular model with a thermoregulation model to predict human blood pressure in unsteady environmental conditions. Our cardiovascular model is a lumped parameter model and consists of 42 segments, which include the entire artery and vein system, divided into 18 segments; the heart, divided into 4 segments; and the pulmonary artery and vein. The vessel parameters were adjusted on the basis of local body blood volume and flow of the thermoregulation model in a thermoneutral environment. Blood pressure under unsteady environmental conditions is predicted by changing the heart rate and vessel resistance of the cardiovascular model which is controlled by blood flow that the thermoregulation model predicts. It is possible to predict the increase in blood pressure under cold environmental conditions and the increase in cardiac output under hot environmental conditions and when bathing. The model was validated by simulating bathing experiments. As the result, the model predicted the peak blood pressure later than the experimental data in a cold environment. To improve the accuracy of the model, it is necessary to consider a method for controlling the heart rate, vessel resistance, and gravity effects after a change in posture.

Original languageEnglish
Article number02062
JournalE3S Web of Conferences
Publication statusPublished - 2019 Aug 13
Event13th REHVA World Congress, CLIMA 2019 - Bucharest, Romania
Duration: 2019 May 262019 May 29


ASJC Scopus subject areas

  • Environmental Science(all)
  • Energy(all)
  • Earth and Planetary Sciences(all)

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