Cristaxenicin A, an antiprotozoal xenicane diterpenoid from the deep sea gorgonian acanthoprimnoa cristata

Shin Taro Ishigami, Yasuyuki Goto, Noboru Inoue, Shin Ichiro Kawazu, Yoshitsugu Matsumoto, Yukimitsu Imahara, Moto Tarumi, Hiromi Nakai, Nobuhiro Fusetani, Yoichi Nakao

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Abstract

A new xenicane diterpenoid, cristaxenicin A (1), has been isolated from the deep sea gorgonian Acanthoprimnoa cristata. The structure of 1 was elucidated on the basis of spectral analysis including NMR and MS. The absolute configuration of 1 was determined on the basis of quantum chemical calculation of CD spectra. Cristaxenicin A (1) showed antiprotozoal activities against Leishmania amazonensis and Trypanosoma congolense with IC50 values of 0.088 and 0.25 μM, respectively.

Original languageEnglish
Pages (from-to)10962-10966
Number of pages5
JournalJournal of Organic Chemistry
Volume77
Issue number23
DOIs
Publication statusPublished - 2012 Dec 7

ASJC Scopus subject areas

  • Organic Chemistry

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    Ishigami, S. T., Goto, Y., Inoue, N., Kawazu, S. I., Matsumoto, Y., Imahara, Y., Tarumi, M., Nakai, H., Fusetani, N., & Nakao, Y. (2012). Cristaxenicin A, an antiprotozoal xenicane diterpenoid from the deep sea gorgonian acanthoprimnoa cristata. Journal of Organic Chemistry, 77(23), 10962-10966. https://doi.org/10.1021/jo302109g