Cristaxenicin A, an antiprotozoal xenicane diterpenoid from the deep sea gorgonian acanthoprimnoa cristata

Shin Taro Ishigami, Yasuyuki Goto, Noboru Inoue, Shin Ichiro Kawazu, Yoshitsugu Matsumoto, Yukimitsu Imahara, Moto Tarumi, Hiromi Nakai, Nobuhiro Fusetani, Youichi Nakao

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    A new xenicane diterpenoid, cristaxenicin A (1), has been isolated from the deep sea gorgonian Acanthoprimnoa cristata. The structure of 1 was elucidated on the basis of spectral analysis including NMR and MS. The absolute configuration of 1 was determined on the basis of quantum chemical calculation of CD spectra. Cristaxenicin A (1) showed antiprotozoal activities against Leishmania amazonensis and Trypanosoma congolense with IC50 values of 0.088 and 0.25 μM, respectively.

    Original languageEnglish
    Pages (from-to)10962-10966
    Number of pages5
    JournalJournal of Organic Chemistry
    Volume77
    Issue number23
    DOIs
    Publication statusPublished - 2012 Dec 7

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    Diterpenes
    Spectrum analysis
    Nuclear magnetic resonance
    cristaxenicin A

    ASJC Scopus subject areas

    • Organic Chemistry

    Cite this

    Cristaxenicin A, an antiprotozoal xenicane diterpenoid from the deep sea gorgonian acanthoprimnoa cristata. / Ishigami, Shin Taro; Goto, Yasuyuki; Inoue, Noboru; Kawazu, Shin Ichiro; Matsumoto, Yoshitsugu; Imahara, Yukimitsu; Tarumi, Moto; Nakai, Hiromi; Fusetani, Nobuhiro; Nakao, Youichi.

    In: Journal of Organic Chemistry, Vol. 77, No. 23, 07.12.2012, p. 10962-10966.

    Research output: Contribution to journalArticle

    Ishigami, ST, Goto, Y, Inoue, N, Kawazu, SI, Matsumoto, Y, Imahara, Y, Tarumi, M, Nakai, H, Fusetani, N & Nakao, Y 2012, 'Cristaxenicin A, an antiprotozoal xenicane diterpenoid from the deep sea gorgonian acanthoprimnoa cristata', Journal of Organic Chemistry, vol. 77, no. 23, pp. 10962-10966. https://doi.org/10.1021/jo302109g
    Ishigami, Shin Taro ; Goto, Yasuyuki ; Inoue, Noboru ; Kawazu, Shin Ichiro ; Matsumoto, Yoshitsugu ; Imahara, Yukimitsu ; Tarumi, Moto ; Nakai, Hiromi ; Fusetani, Nobuhiro ; Nakao, Youichi. / Cristaxenicin A, an antiprotozoal xenicane diterpenoid from the deep sea gorgonian acanthoprimnoa cristata. In: Journal of Organic Chemistry. 2012 ; Vol. 77, No. 23. pp. 10962-10966.
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    AU - Goto, Yasuyuki

    AU - Inoue, Noboru

    AU - Kawazu, Shin Ichiro

    AU - Matsumoto, Yoshitsugu

    AU - Imahara, Yukimitsu

    AU - Tarumi, Moto

    AU - Nakai, Hiromi

    AU - Fusetani, Nobuhiro

    AU - Nakao, Youichi

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