Critical molecular weight effects in the aggregation of phospholipid vesicles triggered by water-soluble polymers and an integrated glycolipid

Shinji Takeoka, Keitaro Sou, Shinya Arase, Takeru Ohgushi, Eishun Tsuchida

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5 Citations (Scopus)


The intervesicular aggregation of phospholipid vesicles is induced by the addition of water-soluble polymers such as poly(ethylene glycol), dextran, etc. due to the interaction between the vesicular surface and the water-soluble polymers. The interaction can be expressed by the critical molecular weight (Mc) of the water-soluble polymers for the aggregation of vesicles. The surface modification of vesicles with glycolipids (O1,O5-bis(octadecyl)N-maltooligonoyl-L-glutamate) accelerates the aggregation of vesicles induced by dextran; therefore, Mc significantly decreased due to the surface modification. No dependence of phospholipid concentration and dextran concentration in an aqueous phase on the Mc indicates that dextran does not act as a cross-linking agent among the vesicles. A clear dependence of the density of the saccharide chains on the vesicular surface on the Mc suggests that dextran should adsorb on the surface of the vesicles by the interaction with the oligosaccharide chains on the surface and cause vesicular aggregation. A lower critical solution temperature was observed for this kind of interaction, and the critical temperature was controlled by changing the molecular weight of dextran.

Original languageEnglish
Pages (from-to)8132-8136
Number of pages5
Issue number25
Publication statusPublished - 1996 Dec 2


ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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