CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain

Ryosuke Takaya, Jun Nagai, Wenfui Piao, Emi Niisato, Takeru Nakabayashi, Yuki Yamazaki, Fumio Nakamura, Naoya Yamashita, Papachan Kolattukudy, Yoshio Goshima, Toshio Ohshima

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Neural circuit formation is a critical process in brain development. Axon guidance molecules, their receptors, and intracellular mediators are important to establish neural circuits. Collapsin response mediator proteins (CRMPs) are known intercellular mediators of a number of repulsive guidance molecules. Studies of mutant mice suggest roles of CRMPs in dendrite development. However, molecular mechanisms of CRMP-mediated dendritic development remain to elucidate. In this study, we show abnormal orientation of basal dendrites (extension to deeper side) of layer V pyramidal neurons in the cerebral cortex of CRMP4−/− mice. Moreover, we observed severe abnormality in orientation of the basal dendrites of these neurons in double knockout of CRMP1 and 4, suggesting redundant functions of these two genes. Redundant gene functions were also observed in proximal bifurcation phenotype in apical dendrites of hippocampal CA1 pyramidal neurons. These results indicate that CRMP1 and CRMP4 regulate proper orientation of the basal dendrites of layer V neurons in the cerebral cortex.

    Original languageEnglish
    Pages (from-to)161-167
    Number of pages7
    JournalBrain Research
    Volume1655
    DOIs
    Publication statusPublished - 2017 Jan 15

    Fingerprint

    Pyramidal Cells
    Dendrites
    Semaphorin-3A
    Brain
    Cerebral Cortex
    Neurons
    Proteins
    Genes
    Phenotype

    Keywords

    • CRMP
    • Dendrite
    • Development
    • Guidance

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Molecular Biology
    • Developmental Biology
    • Clinical Neurology

    Cite this

    CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain. / Takaya, Ryosuke; Nagai, Jun; Piao, Wenfui; Niisato, Emi; Nakabayashi, Takeru; Yamazaki, Yuki; Nakamura, Fumio; Yamashita, Naoya; Kolattukudy, Papachan; Goshima, Yoshio; Ohshima, Toshio.

    In: Brain Research, Vol. 1655, 15.01.2017, p. 161-167.

    Research output: Contribution to journalArticle

    Takaya, R, Nagai, J, Piao, W, Niisato, E, Nakabayashi, T, Yamazaki, Y, Nakamura, F, Yamashita, N, Kolattukudy, P, Goshima, Y & Ohshima, T 2017, 'CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain', Brain Research, vol. 1655, pp. 161-167. https://doi.org/10.1016/j.brainres.2016.11.003
    Takaya, Ryosuke ; Nagai, Jun ; Piao, Wenfui ; Niisato, Emi ; Nakabayashi, Takeru ; Yamazaki, Yuki ; Nakamura, Fumio ; Yamashita, Naoya ; Kolattukudy, Papachan ; Goshima, Yoshio ; Ohshima, Toshio. / CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain. In: Brain Research. 2017 ; Vol. 1655. pp. 161-167.
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