Abstract
Neural circuit formation is a critical process in brain development. Axon guidance molecules, their receptors, and intracellular mediators are important to establish neural circuits. Collapsin response mediator proteins (CRMPs) are known intercellular mediators of a number of repulsive guidance molecules. Studies of mutant mice suggest roles of CRMPs in dendrite development. However, molecular mechanisms of CRMP-mediated dendritic development remain to elucidate. In this study, we show abnormal orientation of basal dendrites (extension to deeper side) of layer V pyramidal neurons in the cerebral cortex of CRMP4−/− mice. Moreover, we observed severe abnormality in orientation of the basal dendrites of these neurons in double knockout of CRMP1 and 4, suggesting redundant functions of these two genes. Redundant gene functions were also observed in proximal bifurcation phenotype in apical dendrites of hippocampal CA1 pyramidal neurons. These results indicate that CRMP1 and CRMP4 regulate proper orientation of the basal dendrites of layer V neurons in the cerebral cortex.
| Original language | English |
|---|---|
| Pages (from-to) | 161-167 |
| Number of pages | 7 |
| Journal | Brain Research |
| Volume | 1655 |
| DOIs | |
| Publication status | Published - 2017 Jan 15 |
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Keywords
- CRMP
- Dendrite
- Development
- Guidance
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Developmental Biology
- Clinical Neurology
Cite this
CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain. / Takaya, Ryosuke; Nagai, Jun; Piao, Wenfui; Niisato, Emi; Nakabayashi, Takeru; Yamazaki, Yuki; Nakamura, Fumio; Yamashita, Naoya; Kolattukudy, Papachan; Goshima, Yoshio; Ohshima, Toshio.
In: Brain Research, Vol. 1655, 15.01.2017, p. 161-167.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain
AU - Takaya, Ryosuke
AU - Nagai, Jun
AU - Piao, Wenfui
AU - Niisato, Emi
AU - Nakabayashi, Takeru
AU - Yamazaki, Yuki
AU - Nakamura, Fumio
AU - Yamashita, Naoya
AU - Kolattukudy, Papachan
AU - Goshima, Yoshio
AU - Ohshima, Toshio
PY - 2017/1/15
Y1 - 2017/1/15
N2 - Neural circuit formation is a critical process in brain development. Axon guidance molecules, their receptors, and intracellular mediators are important to establish neural circuits. Collapsin response mediator proteins (CRMPs) are known intercellular mediators of a number of repulsive guidance molecules. Studies of mutant mice suggest roles of CRMPs in dendrite development. However, molecular mechanisms of CRMP-mediated dendritic development remain to elucidate. In this study, we show abnormal orientation of basal dendrites (extension to deeper side) of layer V pyramidal neurons in the cerebral cortex of CRMP4−/− mice. Moreover, we observed severe abnormality in orientation of the basal dendrites of these neurons in double knockout of CRMP1 and 4, suggesting redundant functions of these two genes. Redundant gene functions were also observed in proximal bifurcation phenotype in apical dendrites of hippocampal CA1 pyramidal neurons. These results indicate that CRMP1 and CRMP4 regulate proper orientation of the basal dendrites of layer V neurons in the cerebral cortex.
AB - Neural circuit formation is a critical process in brain development. Axon guidance molecules, their receptors, and intracellular mediators are important to establish neural circuits. Collapsin response mediator proteins (CRMPs) are known intercellular mediators of a number of repulsive guidance molecules. Studies of mutant mice suggest roles of CRMPs in dendrite development. However, molecular mechanisms of CRMP-mediated dendritic development remain to elucidate. In this study, we show abnormal orientation of basal dendrites (extension to deeper side) of layer V pyramidal neurons in the cerebral cortex of CRMP4−/− mice. Moreover, we observed severe abnormality in orientation of the basal dendrites of these neurons in double knockout of CRMP1 and 4, suggesting redundant functions of these two genes. Redundant gene functions were also observed in proximal bifurcation phenotype in apical dendrites of hippocampal CA1 pyramidal neurons. These results indicate that CRMP1 and CRMP4 regulate proper orientation of the basal dendrites of layer V neurons in the cerebral cortex.
KW - CRMP
KW - Dendrite
KW - Development
KW - Guidance
UR - http://www.scopus.com/inward/record.url?scp=85006371579&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006371579&partnerID=8YFLogxK
U2 - 10.1016/j.brainres.2016.11.003
DO - 10.1016/j.brainres.2016.11.003
M3 - Article
C2 - 27836492
AN - SCOPUS:85006371579
VL - 1655
SP - 161
EP - 167
JO - Brain Research
JF - Brain Research
SN - 0006-8993
ER -