Crmp4 deletion promotes recovery from spinal cord injury by neuroprotection and limited scar formation

Jun Nagai, Yoshiteru Kitamura, Kazuki Owada, Naoya Yamashita, Kohtaro Takei, Yoshio Goshima, Toshio Ohshima

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    Axonal outgrowth inhibitors and scar formation are two major obstacles to central nervous system (CNS) repair. No target molecule that regulates both axonal growth and scarring has been identified. Here we identified collapsin response mediator protein 4 (CRMP4), a common mediator of inhibitory signals after neural injury, as a crucial factor that contributes to both axonal growth inhibition and scarring after spinal cord injury (SCI). We found increases in the inhibitory and toxic forms of CRMP4 in injured spinal cord. Notably, CRMP4 expression was evident in inflammatory cells as well as in neurons after spinal cord transection. Crmp4-/- mice displayed neuroprotection against SCI and reductions in inflammatory response and scar formation. This permissive environment for axonal growth due to CRMP4 deletion restored locomotor activity at an unusually early phase of healing. These results suggest that deletion of CRMP4 is a unique therapeutic strategy that overcomes two obstacles to CNS repair after SCI.

    Original languageEnglish
    Article number8269
    JournalScientific Reports
    Volume5
    DOIs
    Publication statusPublished - 2015 Feb 5

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    Semaphorin-3A
    Spinal Cord Injuries
    Cicatrix
    Proteins
    Central Nervous System
    Growth
    Poisons
    Locomotion
    Spinal Cord
    Neuroprotection
    Neurons
    Wounds and Injuries

    ASJC Scopus subject areas

    • General

    Cite this

    Crmp4 deletion promotes recovery from spinal cord injury by neuroprotection and limited scar formation. / Nagai, Jun; Kitamura, Yoshiteru; Owada, Kazuki; Yamashita, Naoya; Takei, Kohtaro; Goshima, Yoshio; Ohshima, Toshio.

    In: Scientific Reports, Vol. 5, 8269, 05.02.2015.

    Research output: Contribution to journalArticle

    Nagai, Jun ; Kitamura, Yoshiteru ; Owada, Kazuki ; Yamashita, Naoya ; Takei, Kohtaro ; Goshima, Yoshio ; Ohshima, Toshio. / Crmp4 deletion promotes recovery from spinal cord injury by neuroprotection and limited scar formation. In: Scientific Reports. 2015 ; Vol. 5.
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