CRMPs Function in Neurons and Glial Cells

Potential Therapeutic Targets for Neurodegenerative Diseases and CNS Injury

Jun Nagai, Rina Baba, Toshio Ohshima

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Neurodegeneration in the adult mammalian central nervous system (CNS) is fundamentally accelerated by its intrinsic neuronal mechanisms, including its poor regenerative capacity and potent extrinsic inhibitory factors. Thus, the treatment of neurodegenerative diseases faces many obstacles. The degenerative processes, consisting of axonal/dendritic structural disruption, abnormal axonal transport, release of extracellular factors, and inflammation, are often controlled by the cytoskeleton. From this perspective, regulators of the cytoskeleton could potentially be a therapeutic target for neurodegenerative diseases and CNS injury. Collapsin response mediator proteins (CRMPs) are known to regulate the assembly of cytoskeletal proteins in neurons, as well as control axonal growth and neural circuit formation. Recent studies have provided some novel insights into the roles of CRMPs in several inhibitory signaling pathways of neurodegeneration, in addition to its functions in neurological disorders and CNS repair. Here, we summarize the roles of CRMPs in axon regeneration and its emerging functions in non-neuronal cells, especially in inflammatory responses. We also discuss the direct and indirect targeting of CRMPs as a novel therapeutic strategy for neurological diseases.

    Original languageEnglish
    Pages (from-to)1-14
    Number of pages14
    JournalMolecular Neurobiology
    DOIs
    Publication statusAccepted/In press - 2016 Jun 23

    Fingerprint

    Semaphorin-3A
    Nervous System Trauma
    Neuroglia
    Neurodegenerative Diseases
    Central Nervous System
    Neurons
    Cytoskeleton
    Proteins
    Axonal Transport
    Cytoskeletal Proteins
    Therapeutics
    Nervous System Diseases
    Axons
    Regeneration
    Inflammation
    Growth

    Keywords

    • CRMP
    • Cytoskeleton
    • Degeneration
    • Inflammation
    • Neurological diseases
    • Regeneration

    ASJC Scopus subject areas

    • Cellular and Molecular Neuroscience

    Cite this

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    abstract = "Neurodegeneration in the adult mammalian central nervous system (CNS) is fundamentally accelerated by its intrinsic neuronal mechanisms, including its poor regenerative capacity and potent extrinsic inhibitory factors. Thus, the treatment of neurodegenerative diseases faces many obstacles. The degenerative processes, consisting of axonal/dendritic structural disruption, abnormal axonal transport, release of extracellular factors, and inflammation, are often controlled by the cytoskeleton. From this perspective, regulators of the cytoskeleton could potentially be a therapeutic target for neurodegenerative diseases and CNS injury. Collapsin response mediator proteins (CRMPs) are known to regulate the assembly of cytoskeletal proteins in neurons, as well as control axonal growth and neural circuit formation. Recent studies have provided some novel insights into the roles of CRMPs in several inhibitory signaling pathways of neurodegeneration, in addition to its functions in neurological disorders and CNS repair. Here, we summarize the roles of CRMPs in axon regeneration and its emerging functions in non-neuronal cells, especially in inflammatory responses. We also discuss the direct and indirect targeting of CRMPs as a novel therapeutic strategy for neurological diseases.",
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