Abstract
Various features, components, and functions of the immune system present daily variations. Immunocompetent cell counts and cytokine levels present variations according to the time of day and the sleep-wake cycle. Moreover, different immune cell types, such as macrophages, natural killer cells, and lymphocytes, contain a circadian molecular clockwork. The biological clocks intrinsic to immune cells and lymphoid organs, together with inputs from the central pacemaker of the suprachiasmatic nuclei via humoral and neural pathways, regulate the function of cells of the immune system, including their response to signals and their effector functions. Consequences of this include, for example, the daily variation in the response to an immune challenge (e.g., bacterial endotoxin injection) and the circadian control of allergic reactions. The circadian-immune connection is bidirectional, because in addition to this circadian control of immune functions, immune challenges and immune mediators (e.g., cytokines) were shown to have strong effects on circadian rhythms at the molecular, cellular, and behavioral levels. This tight crosstalk between the circadian and immune systems has wide-ranging implications for disease, as shown by the higher incidence of cancer and the exacerbation of autoimmune symptoms upon circadian disruption.
| Original language | English |
|---|---|
| Pages (from-to) | 870-888 |
| Number of pages | 19 |
| Journal | Chronobiology International |
| Volume | 30 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2013 Aug |
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Keywords
- Adaptive immune response
- Allergic reaction
- Circadian rhythm
- Clock gene
- Cytokine
- Innate immune response
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
Cite this
Crosstalk between the circadian clock circuitry and the immune system. / Cermakian, Nicolas; Lange, Tanja; Golombek, Diego; Sarkar, Dipak; Nakao, Atsuhito; Shibata, Shigenobu; Mazzoccoli, Gianluigi.
In: Chronobiology International, Vol. 30, No. 7, 08.2013, p. 870-888.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Crosstalk between the circadian clock circuitry and the immune system
AU - Cermakian, Nicolas
AU - Lange, Tanja
AU - Golombek, Diego
AU - Sarkar, Dipak
AU - Nakao, Atsuhito
AU - Shibata, Shigenobu
AU - Mazzoccoli, Gianluigi
PY - 2013/8
Y1 - 2013/8
N2 - Various features, components, and functions of the immune system present daily variations. Immunocompetent cell counts and cytokine levels present variations according to the time of day and the sleep-wake cycle. Moreover, different immune cell types, such as macrophages, natural killer cells, and lymphocytes, contain a circadian molecular clockwork. The biological clocks intrinsic to immune cells and lymphoid organs, together with inputs from the central pacemaker of the suprachiasmatic nuclei via humoral and neural pathways, regulate the function of cells of the immune system, including their response to signals and their effector functions. Consequences of this include, for example, the daily variation in the response to an immune challenge (e.g., bacterial endotoxin injection) and the circadian control of allergic reactions. The circadian-immune connection is bidirectional, because in addition to this circadian control of immune functions, immune challenges and immune mediators (e.g., cytokines) were shown to have strong effects on circadian rhythms at the molecular, cellular, and behavioral levels. This tight crosstalk between the circadian and immune systems has wide-ranging implications for disease, as shown by the higher incidence of cancer and the exacerbation of autoimmune symptoms upon circadian disruption.
AB - Various features, components, and functions of the immune system present daily variations. Immunocompetent cell counts and cytokine levels present variations according to the time of day and the sleep-wake cycle. Moreover, different immune cell types, such as macrophages, natural killer cells, and lymphocytes, contain a circadian molecular clockwork. The biological clocks intrinsic to immune cells and lymphoid organs, together with inputs from the central pacemaker of the suprachiasmatic nuclei via humoral and neural pathways, regulate the function of cells of the immune system, including their response to signals and their effector functions. Consequences of this include, for example, the daily variation in the response to an immune challenge (e.g., bacterial endotoxin injection) and the circadian control of allergic reactions. The circadian-immune connection is bidirectional, because in addition to this circadian control of immune functions, immune challenges and immune mediators (e.g., cytokines) were shown to have strong effects on circadian rhythms at the molecular, cellular, and behavioral levels. This tight crosstalk between the circadian and immune systems has wide-ranging implications for disease, as shown by the higher incidence of cancer and the exacerbation of autoimmune symptoms upon circadian disruption.
KW - Adaptive immune response
KW - Allergic reaction
KW - Circadian rhythm
KW - Clock gene
KW - Cytokine
KW - Innate immune response
UR - http://www.scopus.com/inward/record.url?scp=84879928320&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879928320&partnerID=8YFLogxK
U2 - 10.3109/07420528.2013.782315
DO - 10.3109/07420528.2013.782315
M3 - Article
VL - 30
SP - 870
EP - 888
JO - Annual Review of Chronopharmacology
JF - Annual Review of Chronopharmacology
SN - 0743-9539
IS - 7
ER -