TY - JOUR
T1 - Crosstalk between the circadian clock circuitry and the immune system
AU - Cermakian, Nicolas
AU - Lange, Tanja
AU - Golombek, Diego
AU - Sarkar, Dipak
AU - Nakao, Atsuhito
AU - Shibata, Shigenobu
AU - Mazzoccoli, Gianluigi
N1 - Funding Information:
This work was supported by ‘‘Italian Ministry of Health’’ grant RC1203ME46 through Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital ‘‘Casa Sollievo della Sofferenza,’’ Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy; the Canadian Institutes for Health Research; the Natural Science and Engineering Research Council and the Fonds de Recherche du Québec—Santé; and by the National Institutes of Health grants R37 AA08757, R01 AA015718, and R01 HL088041.
PY - 2013/8
Y1 - 2013/8
N2 - Various features, components, and functions of the immune system present daily variations. Immunocompetent cell counts and cytokine levels present variations according to the time of day and the sleep-wake cycle. Moreover, different immune cell types, such as macrophages, natural killer cells, and lymphocytes, contain a circadian molecular clockwork. The biological clocks intrinsic to immune cells and lymphoid organs, together with inputs from the central pacemaker of the suprachiasmatic nuclei via humoral and neural pathways, regulate the function of cells of the immune system, including their response to signals and their effector functions. Consequences of this include, for example, the daily variation in the response to an immune challenge (e.g., bacterial endotoxin injection) and the circadian control of allergic reactions. The circadian-immune connection is bidirectional, because in addition to this circadian control of immune functions, immune challenges and immune mediators (e.g., cytokines) were shown to have strong effects on circadian rhythms at the molecular, cellular, and behavioral levels. This tight crosstalk between the circadian and immune systems has wide-ranging implications for disease, as shown by the higher incidence of cancer and the exacerbation of autoimmune symptoms upon circadian disruption.
AB - Various features, components, and functions of the immune system present daily variations. Immunocompetent cell counts and cytokine levels present variations according to the time of day and the sleep-wake cycle. Moreover, different immune cell types, such as macrophages, natural killer cells, and lymphocytes, contain a circadian molecular clockwork. The biological clocks intrinsic to immune cells and lymphoid organs, together with inputs from the central pacemaker of the suprachiasmatic nuclei via humoral and neural pathways, regulate the function of cells of the immune system, including their response to signals and their effector functions. Consequences of this include, for example, the daily variation in the response to an immune challenge (e.g., bacterial endotoxin injection) and the circadian control of allergic reactions. The circadian-immune connection is bidirectional, because in addition to this circadian control of immune functions, immune challenges and immune mediators (e.g., cytokines) were shown to have strong effects on circadian rhythms at the molecular, cellular, and behavioral levels. This tight crosstalk between the circadian and immune systems has wide-ranging implications for disease, as shown by the higher incidence of cancer and the exacerbation of autoimmune symptoms upon circadian disruption.
KW - Adaptive immune response
KW - Allergic reaction
KW - Circadian rhythm
KW - Clock gene
KW - Cytokine
KW - Innate immune response
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U2 - 10.3109/07420528.2013.782315
DO - 10.3109/07420528.2013.782315
M3 - Article
C2 - 23697902
AN - SCOPUS:84879928320
VL - 30
SP - 870
EP - 888
JO - Annual Review of Chronopharmacology
JF - Annual Review of Chronopharmacology
SN - 0743-9539
IS - 7
ER -