CTRP3 plays an important role in the development of collagen-induced arthritis in mice

Masanori A. Murayama, Shigeru Kakuta, Takumi Maruhashi, Kenji Shimizu, Akimasa Seno, Sachiko Kubo, Nozomi Sato, Shinobu Saijo, Masahira Hattori, Yoichiro Iwakura

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease exhibited most commonly in joints. We found that the expression of C1qtnf3, which encodes C1q/TNF-related protein 3 (CTRP3), was highly increased in two mouse RA models with different etiology. To elucidate the pathogenic roles of CTRP3 in the development of arthritis, we generated C1qtnf3-/- mice and examined the development of collagen-induced arthritis in these mice. We found that the incidence and severity score was higher in C1qtnf3-/- mice compared with wild-type (WT) mice. Histopathology of the joints was also more severe in C1qtnf3-/- mice. The levels of antibodies against type II collagen and pro-inflammatory cytokine mRNAs in C1qtnf3-/- mice were higher than WT mice. These observations indicate that CTRP3 plays an important role in the development of autoimmune arthritis, suggesting CTRP3 as a possible medicine to treat RA.

Original languageEnglish
Pages (from-to)42-48
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume443
Issue number1
DOIs
Publication statusPublished - 2014 Jan 3
Externally publishedYes

Keywords

  • Collagen-induced arthritis
  • CTRP3
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

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