CTRP3 plays an important role in the development of collagen-induced arthritis in mice

Masanori A. Murayama, Shigeru Kakuta, Takumi Maruhashi, Kenji Shimizu, Akimasa Seno, Sachiko Kubo, Nozomi Sato, Shinobu Saijo, Masahira Hattori, Yoichiro Iwakura

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease exhibited most commonly in joints. We found that the expression of C1qtnf3, which encodes C1q/TNF-related protein 3 (CTRP3), was highly increased in two mouse RA models with different etiology. To elucidate the pathogenic roles of CTRP3 in the development of arthritis, we generated C1qtnf3-/- mice and examined the development of collagen-induced arthritis in these mice. We found that the incidence and severity score was higher in C1qtnf3-/- mice compared with wild-type (WT) mice. Histopathology of the joints was also more severe in C1qtnf3-/- mice. The levels of antibodies against type II collagen and pro-inflammatory cytokine mRNAs in C1qtnf3-/- mice were higher than WT mice. These observations indicate that CTRP3 plays an important role in the development of autoimmune arthritis, suggesting CTRP3 as a possible medicine to treat RA.

Original languageEnglish
Pages (from-to)42-48
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume443
Issue number1
DOIs
Publication statusPublished - 2014 Jan 3
Externally publishedYes

Fingerprint

Experimental Arthritis
Collagen
Proteins
Rheumatoid Arthritis
Collagen Type II
Medicine
Arthritis
Joints
Cytokines
Messenger RNA
Antibodies
Autoimmune Diseases
Incidence

Keywords

  • Collagen-induced arthritis
  • CTRP3
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Murayama, M. A., Kakuta, S., Maruhashi, T., Shimizu, K., Seno, A., Kubo, S., ... Iwakura, Y. (2014). CTRP3 plays an important role in the development of collagen-induced arthritis in mice. Biochemical and Biophysical Research Communications, 443(1), 42-48. https://doi.org/10.1016/j.bbrc.2013.11.040

CTRP3 plays an important role in the development of collagen-induced arthritis in mice. / Murayama, Masanori A.; Kakuta, Shigeru; Maruhashi, Takumi; Shimizu, Kenji; Seno, Akimasa; Kubo, Sachiko; Sato, Nozomi; Saijo, Shinobu; Hattori, Masahira; Iwakura, Yoichiro.

In: Biochemical and Biophysical Research Communications, Vol. 443, No. 1, 03.01.2014, p. 42-48.

Research output: Contribution to journalArticle

Murayama, MA, Kakuta, S, Maruhashi, T, Shimizu, K, Seno, A, Kubo, S, Sato, N, Saijo, S, Hattori, M & Iwakura, Y 2014, 'CTRP3 plays an important role in the development of collagen-induced arthritis in mice', Biochemical and Biophysical Research Communications, vol. 443, no. 1, pp. 42-48. https://doi.org/10.1016/j.bbrc.2013.11.040
Murayama, Masanori A. ; Kakuta, Shigeru ; Maruhashi, Takumi ; Shimizu, Kenji ; Seno, Akimasa ; Kubo, Sachiko ; Sato, Nozomi ; Saijo, Shinobu ; Hattori, Masahira ; Iwakura, Yoichiro. / CTRP3 plays an important role in the development of collagen-induced arthritis in mice. In: Biochemical and Biophysical Research Communications. 2014 ; Vol. 443, No. 1. pp. 42-48.
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