Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle

Yuki Aoi, Kunio Arai, Masaya Miyamoto, Yuji Katsuta, Akira Yamashita, Masamitsu Sato, Masayuki Yamamoto

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The number of nuclear divisions in meiosis is strictly limited to two. Although the precise mechanism remains unknown, this seems to be achieved by adjusting the anaphase-promoting complex/cyclosome (APC/C) activity to degrade cyclin. Here, we describe a fission yeast cuf2 mutant that enters into a third nuclear division cycle, represented by ectopic spindle assembly and abnormal chromosome segregation. Cuf2 is a meiotic transcription factor, and its critical target is fzr1+/mfr1+, which encodes a meiotic APC/C activator. fzr1Δ also enters a third nuclear division. Thus, Cuf2 ensures termination of the M-phase cycle by boosting Fzr1 expression to generate functional gametes.

Original languageEnglish
Pages (from-to)553-560
Number of pages8
JournalEMBO Reports
Volume14
Issue number6
DOIs
Publication statusPublished - 2013 Jun 1

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Keywords

  • APC/C
  • Cdk
  • cell cycle
  • cyclin destruction
  • meiosis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Aoi, Y., Arai, K., Miyamoto, M., Katsuta, Y., Yamashita, A., Sato, M., & Yamamoto, M. (2013). Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle. EMBO Reports, 14(6), 553-560. https://doi.org/10.1038/embor.2013.52