Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle

Yuki Aoi, Kunio Arai, Masaya Miyamoto, Yuji Katsuta, Akira Yamashita, Masamitsu Sato, Masayuki Yamamoto

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    The number of nuclear divisions in meiosis is strictly limited to two. Although the precise mechanism remains unknown, this seems to be achieved by adjusting the anaphase-promoting complex/cyclosome (APC/C) activity to degrade cyclin. Here, we describe a fission yeast cuf2 mutant that enters into a third nuclear division cycle, represented by ectopic spindle assembly and abnormal chromosome segregation. Cuf2 is a meiotic transcription factor, and its critical target is fzr1+/mfr1+, which encodes a meiotic APC/C activator. fzr1Δ also enters a third nuclear division. Thus, Cuf2 ensures termination of the M-phase cycle by boosting Fzr1 expression to generate functional gametes.

    Original languageEnglish
    Pages (from-to)553-560
    Number of pages8
    JournalEMBO Reports
    Volume14
    Issue number6
    DOIs
    Publication statusPublished - 2013 Jun

    Fingerprint

    Anaphase-Promoting Complex-Cyclosome
    Cell Nucleus Division
    Transcription
    Cyclins
    Chromosomes
    Yeast
    Chromosome Segregation
    Transcription Factors
    Schizosaccharomyces
    Meiosis
    Germ Cells
    Cell Division

    Keywords

    • APC/C
    • Cdk
    • cell cycle
    • cyclin destruction
    • meiosis

    ASJC Scopus subject areas

    • Genetics
    • Molecular Biology
    • Biochemistry

    Cite this

    Aoi, Y., Arai, K., Miyamoto, M., Katsuta, Y., Yamashita, A., Sato, M., & Yamamoto, M. (2013). Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle. EMBO Reports, 14(6), 553-560. https://doi.org/10.1038/embor.2013.52

    Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle. / Aoi, Yuki; Arai, Kunio; Miyamoto, Masaya; Katsuta, Yuji; Yamashita, Akira; Sato, Masamitsu; Yamamoto, Masayuki.

    In: EMBO Reports, Vol. 14, No. 6, 06.2013, p. 553-560.

    Research output: Contribution to journalArticle

    Aoi, Y, Arai, K, Miyamoto, M, Katsuta, Y, Yamashita, A, Sato, M & Yamamoto, M 2013, 'Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle', EMBO Reports, vol. 14, no. 6, pp. 553-560. https://doi.org/10.1038/embor.2013.52
    Aoi, Yuki ; Arai, Kunio ; Miyamoto, Masaya ; Katsuta, Yuji ; Yamashita, Akira ; Sato, Masamitsu ; Yamamoto, Masayuki. / Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle. In: EMBO Reports. 2013 ; Vol. 14, No. 6. pp. 553-560.
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