Curcumin attenuates oxidative stress following downhill running-induced muscle damage

Noriaki Kawanishi, Koki Kato, Masaki Takahashi, Tsubasa Mizokami, Yoshihiko Otsuka, Atsushi Imaizumi, Daisuke Shiva, Hiromi Yano, Katsuhiko Suzuki

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Downhill running causes muscle damage, and induces oxidative stress and inflammatory reaction. Recently, it is shown that curcumin possesses anti-oxidant and anti-inflammatory potentials. Interestingly, curcumin reduces inflammatory cytokine concentrations in skeletal muscle after downhill running of mice. However, it is not known whether curcumin affects oxidative stress after downhill running-induced muscle damage. Therefore, the purpose of this study was to investigate the effects of curcumin on oxidative stress following downhill running induced-muscle damage. We also investigated whether curcumin affects macrophage infiltration via chemokines such as MCP-1 and CXCL14. Male C57BL/6 mice were divided into four groups; rest, rest plus curcumin, downhill running, or downhill running plus curcumin. Downhill running mice ran at 22. m/min, -15% grade on the treadmill for 150. min. Curcumin (3. mg) was administered in oral administration immediately after downhill running. Hydrogen peroxide concentration and NADPH-oxidase mRNA expression in the downhill running mice were significantly higher than those in the rest mice, but these variables were significantly attenuated by curcumin administration in downhill running mice. In addition, mRNA expression levels of MCP-1, CXCL14 and F4/80 reflecting presence of macrophages in the downhill running mice were significantly higher than those in the rest mice. However, MCP-1 and F4/80 mRNA expression levels were significantly attenuated by curcumin administration in downhill running mice. Curcumin may attenuate oxidative stress following downhill running-induced muscle damage.

Original languageEnglish
Pages (from-to)573-578
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume441
Issue number3
DOIs
Publication statusPublished - 2013 Nov 22

Fingerprint

Curcumin
Oxidative stress
Running
Muscle
Oxidative Stress
Muscles
Macrophages
Messenger RNA
Exercise equipment
NADPH Oxidase
Chemokines
Infiltration
Oxidants
Hydrogen Peroxide
Inbred C57BL Mouse
Anti-Inflammatory Agents
Oral Administration
Cytokines
Skeletal Muscle

Keywords

  • Curcumin
  • Downhill running
  • Macrophage
  • Oxidative stress
  • Skeletal muscle

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Curcumin attenuates oxidative stress following downhill running-induced muscle damage. / Kawanishi, Noriaki; Kato, Koki; Takahashi, Masaki; Mizokami, Tsubasa; Otsuka, Yoshihiko; Imaizumi, Atsushi; Shiva, Daisuke; Yano, Hiromi; Suzuki, Katsuhiko.

In: Biochemical and Biophysical Research Communications, Vol. 441, No. 3, 22.11.2013, p. 573-578.

Research output: Contribution to journalArticle

Kawanishi, Noriaki ; Kato, Koki ; Takahashi, Masaki ; Mizokami, Tsubasa ; Otsuka, Yoshihiko ; Imaizumi, Atsushi ; Shiva, Daisuke ; Yano, Hiromi ; Suzuki, Katsuhiko. / Curcumin attenuates oxidative stress following downhill running-induced muscle damage. In: Biochemical and Biophysical Research Communications. 2013 ; Vol. 441, No. 3. pp. 573-578.
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