Cutaneous approach towards clinical and pathophysiological aspects of hyperglycemia by ATR FTIR spectroscopy

Natalja Skrebova Eikje, Takayuki Sota, Katsuo Aizawa

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Attempts were made to non-invasively detect glucose-specific spectral signals in the skin by ATR-FTIR spectroscopy. In vivo spectra were collected from the inner wrists of healthy, prediabetes and diabetes subjects in the 750-4000 cm-1 region, with a closer assessment of the glucose-related region between 1000 and 1180 cm-1. Spectra in vivo showed glucose-specific peaks at 1030, 1080, 1118 and 1151 cm-1, as a variety of glucose solutions are found in vitro. Based on the differences of intensities at 1030 and 1118 cm-1 two spectral patterns were seen: I1118 > I1030 for a diabetes and I1030 > I1118 for non-diabetes subjects. The peak at 1030 cm-1 was used to assess glucose concentrations in the skin due to its good correlation with glucose concentrations in vitro. Calculated mean values of the peak at 1030 cm-1 showed evidence of correlation with blood glucose levels when grouped as = 140, 140-200 and = 200 mg/dL, though there was no constant correlation between them when compared before/after OGTT or at the fasting/postprandial states. Absorbances at 1030 cm-1 were not only increased in a dose-dependent manner in a diabetes patient, but were also generally higher than in non-diabetes subjects at 30 min OGTT assessment. Also we could monitor absorbances at 1030 cm-1 and determine their changes in the skin tissue at different times of OGTT. We assume that our approach to in vivo measurement and monitoring of glucose concentrations at 1030 cm-1 may be one of the indicators to assess glucose activity level and its changes in the skin tissue, and has further implications in the study of clinical and pathophysiological aspects of hyperglycemia in diabetes and non-diabetes subjects by ATR-FTIR spectroscopy.

    Original languageEnglish
    Title of host publicationOptics InfoBase Conference Papers
    PublisherOptical Society of America
    ISBN (Print)9780819467713
    Publication statusPublished - 2007
    EventEuropean Conference on Biomedical Optics, ECBO 2007 - Munich
    Duration: 2007 Jun 172007 Jun 17

    Other

    OtherEuropean Conference on Biomedical Optics, ECBO 2007
    CityMunich
    Period07/6/1707/6/17

    Fingerprint

    hyperglycemia
    glucose
    Glucose
    Spectroscopy
    spectroscopy
    Medical problems
    Skin
    fasting
    Tissue
    wrist
    blood
    Blood

    Keywords

    • ATR technique
    • Diabetes mellitus
    • Fourier transform infrared spectroscopy
    • Glucose
    • Hyperglycemia
    • In vivo skin
    • Non-invasive measurement
    • Skin biochemistry
    • Skin metabolism
    • Skin patho/physiology

    ASJC Scopus subject areas

    • Instrumentation
    • Atomic and Molecular Physics, and Optics

    Cite this

    Eikje, N. S., Sota, T., & Aizawa, K. (2007). Cutaneous approach towards clinical and pathophysiological aspects of hyperglycemia by ATR FTIR spectroscopy. In Optics InfoBase Conference Papers Optical Society of America.

    Cutaneous approach towards clinical and pathophysiological aspects of hyperglycemia by ATR FTIR spectroscopy. / Eikje, Natalja Skrebova; Sota, Takayuki; Aizawa, Katsuo.

    Optics InfoBase Conference Papers. Optical Society of America, 2007.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Eikje, NS, Sota, T & Aizawa, K 2007, Cutaneous approach towards clinical and pathophysiological aspects of hyperglycemia by ATR FTIR spectroscopy. in Optics InfoBase Conference Papers. Optical Society of America, European Conference on Biomedical Optics, ECBO 2007, Munich, 07/6/17.
    Eikje NS, Sota T, Aizawa K. Cutaneous approach towards clinical and pathophysiological aspects of hyperglycemia by ATR FTIR spectroscopy. In Optics InfoBase Conference Papers. Optical Society of America. 2007
    Eikje, Natalja Skrebova ; Sota, Takayuki ; Aizawa, Katsuo. / Cutaneous approach towards clinical and pathophysiological aspects of hyperglycemia by ATR FTIR spectroscopy. Optics InfoBase Conference Papers. Optical Society of America, 2007.
    @inproceedings{b7a99365b65146a5a858fb18e8e56b35,
    title = "Cutaneous approach towards clinical and pathophysiological aspects of hyperglycemia by ATR FTIR spectroscopy",
    abstract = "Attempts were made to non-invasively detect glucose-specific spectral signals in the skin by ATR-FTIR spectroscopy. In vivo spectra were collected from the inner wrists of healthy, prediabetes and diabetes subjects in the 750-4000 cm-1 region, with a closer assessment of the glucose-related region between 1000 and 1180 cm-1. Spectra in vivo showed glucose-specific peaks at 1030, 1080, 1118 and 1151 cm-1, as a variety of glucose solutions are found in vitro. Based on the differences of intensities at 1030 and 1118 cm-1 two spectral patterns were seen: I1118 > I1030 for a diabetes and I1030 > I1118 for non-diabetes subjects. The peak at 1030 cm-1 was used to assess glucose concentrations in the skin due to its good correlation with glucose concentrations in vitro. Calculated mean values of the peak at 1030 cm-1 showed evidence of correlation with blood glucose levels when grouped as = 140, 140-200 and = 200 mg/dL, though there was no constant correlation between them when compared before/after OGTT or at the fasting/postprandial states. Absorbances at 1030 cm-1 were not only increased in a dose-dependent manner in a diabetes patient, but were also generally higher than in non-diabetes subjects at 30 min OGTT assessment. Also we could monitor absorbances at 1030 cm-1 and determine their changes in the skin tissue at different times of OGTT. We assume that our approach to in vivo measurement and monitoring of glucose concentrations at 1030 cm-1 may be one of the indicators to assess glucose activity level and its changes in the skin tissue, and has further implications in the study of clinical and pathophysiological aspects of hyperglycemia in diabetes and non-diabetes subjects by ATR-FTIR spectroscopy.",
    keywords = "ATR technique, Diabetes mellitus, Fourier transform infrared spectroscopy, Glucose, Hyperglycemia, In vivo skin, Non-invasive measurement, Skin biochemistry, Skin metabolism, Skin patho/physiology",
    author = "Eikje, {Natalja Skrebova} and Takayuki Sota and Katsuo Aizawa",
    year = "2007",
    language = "English",
    isbn = "9780819467713",
    booktitle = "Optics InfoBase Conference Papers",
    publisher = "Optical Society of America",

    }

    TY - GEN

    T1 - Cutaneous approach towards clinical and pathophysiological aspects of hyperglycemia by ATR FTIR spectroscopy

    AU - Eikje, Natalja Skrebova

    AU - Sota, Takayuki

    AU - Aizawa, Katsuo

    PY - 2007

    Y1 - 2007

    N2 - Attempts were made to non-invasively detect glucose-specific spectral signals in the skin by ATR-FTIR spectroscopy. In vivo spectra were collected from the inner wrists of healthy, prediabetes and diabetes subjects in the 750-4000 cm-1 region, with a closer assessment of the glucose-related region between 1000 and 1180 cm-1. Spectra in vivo showed glucose-specific peaks at 1030, 1080, 1118 and 1151 cm-1, as a variety of glucose solutions are found in vitro. Based on the differences of intensities at 1030 and 1118 cm-1 two spectral patterns were seen: I1118 > I1030 for a diabetes and I1030 > I1118 for non-diabetes subjects. The peak at 1030 cm-1 was used to assess glucose concentrations in the skin due to its good correlation with glucose concentrations in vitro. Calculated mean values of the peak at 1030 cm-1 showed evidence of correlation with blood glucose levels when grouped as = 140, 140-200 and = 200 mg/dL, though there was no constant correlation between them when compared before/after OGTT or at the fasting/postprandial states. Absorbances at 1030 cm-1 were not only increased in a dose-dependent manner in a diabetes patient, but were also generally higher than in non-diabetes subjects at 30 min OGTT assessment. Also we could monitor absorbances at 1030 cm-1 and determine their changes in the skin tissue at different times of OGTT. We assume that our approach to in vivo measurement and monitoring of glucose concentrations at 1030 cm-1 may be one of the indicators to assess glucose activity level and its changes in the skin tissue, and has further implications in the study of clinical and pathophysiological aspects of hyperglycemia in diabetes and non-diabetes subjects by ATR-FTIR spectroscopy.

    AB - Attempts were made to non-invasively detect glucose-specific spectral signals in the skin by ATR-FTIR spectroscopy. In vivo spectra were collected from the inner wrists of healthy, prediabetes and diabetes subjects in the 750-4000 cm-1 region, with a closer assessment of the glucose-related region between 1000 and 1180 cm-1. Spectra in vivo showed glucose-specific peaks at 1030, 1080, 1118 and 1151 cm-1, as a variety of glucose solutions are found in vitro. Based on the differences of intensities at 1030 and 1118 cm-1 two spectral patterns were seen: I1118 > I1030 for a diabetes and I1030 > I1118 for non-diabetes subjects. The peak at 1030 cm-1 was used to assess glucose concentrations in the skin due to its good correlation with glucose concentrations in vitro. Calculated mean values of the peak at 1030 cm-1 showed evidence of correlation with blood glucose levels when grouped as = 140, 140-200 and = 200 mg/dL, though there was no constant correlation between them when compared before/after OGTT or at the fasting/postprandial states. Absorbances at 1030 cm-1 were not only increased in a dose-dependent manner in a diabetes patient, but were also generally higher than in non-diabetes subjects at 30 min OGTT assessment. Also we could monitor absorbances at 1030 cm-1 and determine their changes in the skin tissue at different times of OGTT. We assume that our approach to in vivo measurement and monitoring of glucose concentrations at 1030 cm-1 may be one of the indicators to assess glucose activity level and its changes in the skin tissue, and has further implications in the study of clinical and pathophysiological aspects of hyperglycemia in diabetes and non-diabetes subjects by ATR-FTIR spectroscopy.

    KW - ATR technique

    KW - Diabetes mellitus

    KW - Fourier transform infrared spectroscopy

    KW - Glucose

    KW - Hyperglycemia

    KW - In vivo skin

    KW - Non-invasive measurement

    KW - Skin biochemistry

    KW - Skin metabolism

    KW - Skin patho/physiology

    UR - http://www.scopus.com/inward/record.url?scp=84898807219&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84898807219&partnerID=8YFLogxK

    M3 - Conference contribution

    AN - SCOPUS:84898807219

    SN - 9780819467713

    BT - Optics InfoBase Conference Papers

    PB - Optical Society of America

    ER -