Cyanation of Phenol Derivatives with Aminoacetonitriles by Nickel Catalysis

Ryosuke Takise, Kenichiro Itami, Junichiro Yamaguchi

    Research output: Contribution to journalArticle

    47 Citations (Scopus)


    Generation of useful arylnitrile structures from simple aromatic feedstock chemicals represents a fundamentally important reaction in chemical synthesis. The first nickel-catalyzed cyanation of phenol derivatives with metal-free cyanating agents, aminoacetonitriles, is described. A nickel-based catalytic system consisting of a unique diphosphine ligand such as dcype or dcypt enables the cyanation of versatile phenol derivatives such as aryl carbamates and aryl pivalates. The use of aminoacetonitriles as a cyanating agent leads to an environmentally and easy-to-use method for arylnitrile synthesis.

    Original languageEnglish
    Pages (from-to)4428-4431
    Number of pages4
    JournalOrganic Letters
    Issue number17
    Publication statusPublished - 2016 Sep 2

    ASJC Scopus subject areas

    • Biochemistry
    • Medicine(all)
    • Physical and Theoretical Chemistry
    • Organic Chemistry

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