Cyanation of Phenol Derivatives with Aminoacetonitriles by Nickel Catalysis

Ryosuke Takise, Kenichiro Itami*, Junichiro Yamaguchi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

69 Citations (Scopus)


Generation of useful arylnitrile structures from simple aromatic feedstock chemicals represents a fundamentally important reaction in chemical synthesis. The first nickel-catalyzed cyanation of phenol derivatives with metal-free cyanating agents, aminoacetonitriles, is described. A nickel-based catalytic system consisting of a unique diphosphine ligand such as dcype or dcypt enables the cyanation of versatile phenol derivatives such as aryl carbamates and aryl pivalates. The use of aminoacetonitriles as a cyanating agent leads to an environmentally and easy-to-use method for arylnitrile synthesis.

Original languageEnglish
Pages (from-to)4428-4431
Number of pages4
JournalOrganic Letters
Issue number17
Publication statusPublished - 2016 Sept 2

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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