Cyanation of Phenol Derivatives with Aminoacetonitriles by Nickel Catalysis

Ryosuke Takise, Kenichiro Itami, Junichiro Yamaguchi

    Research output: Contribution to journalArticle

    37 Citations (Scopus)

    Abstract

    Generation of useful arylnitrile structures from simple aromatic feedstock chemicals represents a fundamentally important reaction in chemical synthesis. The first nickel-catalyzed cyanation of phenol derivatives with metal-free cyanating agents, aminoacetonitriles, is described. A nickel-based catalytic system consisting of a unique diphosphine ligand such as dcype or dcypt enables the cyanation of versatile phenol derivatives such as aryl carbamates and aryl pivalates. The use of aminoacetonitriles as a cyanating agent leads to an environmentally and easy-to-use method for arylnitrile synthesis.

    Original languageEnglish
    Pages (from-to)4428-4431
    Number of pages4
    JournalOrganic Letters
    Volume18
    Issue number17
    DOIs
    Publication statusPublished - 2016 Sep 2

    Fingerprint

    Aminoacetonitrile
    Phenol
    Nickel
    Catalysis
    phenols
    catalysis
    nickel
    Derivatives
    Carbamates
    synthesis
    Feedstocks
    Metals
    Ligands
    ligands
    metals

    ASJC Scopus subject areas

    • Biochemistry
    • Medicine(all)
    • Physical and Theoretical Chemistry
    • Organic Chemistry

    Cite this

    Cyanation of Phenol Derivatives with Aminoacetonitriles by Nickel Catalysis. / Takise, Ryosuke; Itami, Kenichiro; Yamaguchi, Junichiro.

    In: Organic Letters, Vol. 18, No. 17, 02.09.2016, p. 4428-4431.

    Research output: Contribution to journalArticle

    Takise, Ryosuke ; Itami, Kenichiro ; Yamaguchi, Junichiro. / Cyanation of Phenol Derivatives with Aminoacetonitriles by Nickel Catalysis. In: Organic Letters. 2016 ; Vol. 18, No. 17. pp. 4428-4431.
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