TY - JOUR
T1 - Cyanation of Phenol Derivatives with Aminoacetonitriles by Nickel Catalysis
AU - Takise, Ryosuke
AU - Itami, Kenichiro
AU - Yamaguchi, Junichiro
N1 - Funding Information:
This work was supported by the ERATO program from JST (K.I.), JSPS KAKENHI Grant Nos. JP16H01011 and JP16H04148 (to J.Y.), and a JSPS research fellowship for youngscientists(toR.T.)
Publisher Copyright:
© 2016 American Chemical Society.
PY - 2016/9/2
Y1 - 2016/9/2
N2 - Generation of useful arylnitrile structures from simple aromatic feedstock chemicals represents a fundamentally important reaction in chemical synthesis. The first nickel-catalyzed cyanation of phenol derivatives with metal-free cyanating agents, aminoacetonitriles, is described. A nickel-based catalytic system consisting of a unique diphosphine ligand such as dcype or dcypt enables the cyanation of versatile phenol derivatives such as aryl carbamates and aryl pivalates. The use of aminoacetonitriles as a cyanating agent leads to an environmentally and easy-to-use method for arylnitrile synthesis.
AB - Generation of useful arylnitrile structures from simple aromatic feedstock chemicals represents a fundamentally important reaction in chemical synthesis. The first nickel-catalyzed cyanation of phenol derivatives with metal-free cyanating agents, aminoacetonitriles, is described. A nickel-based catalytic system consisting of a unique diphosphine ligand such as dcype or dcypt enables the cyanation of versatile phenol derivatives such as aryl carbamates and aryl pivalates. The use of aminoacetonitriles as a cyanating agent leads to an environmentally and easy-to-use method for arylnitrile synthesis.
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U2 - 10.1021/acs.orglett.6b02265
DO - 10.1021/acs.orglett.6b02265
M3 - Article
AN - SCOPUS:84986887480
SN - 1523-7060
VL - 18
SP - 4428
EP - 4431
JO - Organic Letters
JF - Organic Letters
IS - 17
ER -