Cyclic change of cytokines in a patient with cyclic thrombocytopenia

Fumihiko Kimura, Yukistugu Nakamura, Ken Sato, Naoki Wakimoto, Takashi Kato, Tomoyuki Tahara, Muneo Yamada, Naokazu Nagata, Kazuo Motoyoshi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The serial change of various cytokines in the serum from a patient with cyclic thrombocytopenia is described, Interleukin 7, stem cell factor, and transforming growth factor β1 synchronized with the platelet count, and there was a significant positive correlation between the three cytokines and the platelet count. Levels of macrophage colony-stimulating factor, thrombopoietin, platelet-associated IgG and erythropoietin changed reciprocally with the platelet count, and there was a significant negative correlation between the platelet count and these cytokines except erythropoietin. No cyclic change was observed in IL-3, IL-6, IL-11, granulocyte-macrophage colony-stimulating factor, or leukaemia inhibitory factor. These observations suggest that this disease involves two cyclic changes: megakaryocytopoiesis and platelet destruction, in both of which the cytokines play an important role.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalBritish Journal of Haematology
Volume94
Issue number1
Publication statusPublished - 1996
Externally publishedYes

Fingerprint

Platelet Count
Cytokines
Erythropoietin
Blood Platelets
Interleukin-11
Thrombopoiesis
Thrombopoietin
Leukemia Inhibitory Factor
Interleukin-7
Stem Cell Factor
Macrophage Colony-Stimulating Factor
Interleukin-3
Transforming Growth Factors
Granulocyte-Macrophage Colony-Stimulating Factor
Interleukin-6
Immunoglobulin G
Cyclic Thrombocytopenia
Serum

Keywords

  • Cyclic thrombocytopenia
  • Interleukin-7
  • M-CSF
  • Stem cell factor
  • Thrombopoietin

ASJC Scopus subject areas

  • Hematology

Cite this

Kimura, F., Nakamura, Y., Sato, K., Wakimoto, N., Kato, T., Tahara, T., ... Motoyoshi, K. (1996). Cyclic change of cytokines in a patient with cyclic thrombocytopenia. British Journal of Haematology, 94(1), 171-174.

Cyclic change of cytokines in a patient with cyclic thrombocytopenia. / Kimura, Fumihiko; Nakamura, Yukistugu; Sato, Ken; Wakimoto, Naoki; Kato, Takashi; Tahara, Tomoyuki; Yamada, Muneo; Nagata, Naokazu; Motoyoshi, Kazuo.

In: British Journal of Haematology, Vol. 94, No. 1, 1996, p. 171-174.

Research output: Contribution to journalArticle

Kimura, F, Nakamura, Y, Sato, K, Wakimoto, N, Kato, T, Tahara, T, Yamada, M, Nagata, N & Motoyoshi, K 1996, 'Cyclic change of cytokines in a patient with cyclic thrombocytopenia', British Journal of Haematology, vol. 94, no. 1, pp. 171-174.
Kimura F, Nakamura Y, Sato K, Wakimoto N, Kato T, Tahara T et al. Cyclic change of cytokines in a patient with cyclic thrombocytopenia. British Journal of Haematology. 1996;94(1):171-174.
Kimura, Fumihiko ; Nakamura, Yukistugu ; Sato, Ken ; Wakimoto, Naoki ; Kato, Takashi ; Tahara, Tomoyuki ; Yamada, Muneo ; Nagata, Naokazu ; Motoyoshi, Kazuo. / Cyclic change of cytokines in a patient with cyclic thrombocytopenia. In: British Journal of Haematology. 1996 ; Vol. 94, No. 1. pp. 171-174.
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