Background: Cdk5 is a kinase involved in the various neuronal processes. Results: Cdk5 directly phosphorylates CLOCK and regulates its transcriptional activity in association with altered stability and subcellular distribution. Conclusion: Cdk5 functions as a regulator of CLOCK protein. Significance: Our findings may provide mechanistic links between diverse Cdk5-mediated brain functions and the molecular clock.
|Number of pages||12|
|Journal||Journal of Biological Chemistry|
|Publication status||Published - 2013 Dec 27|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology