Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation

Yongdo Kwak, Jaehoon Jeong, Saebom Lee, Young Un Park, Seol Ae Lee, Dong Hee Han, Joung Hun Kim, Toshio Ohshima, Katsuhiko Mikoshiba, Yoo Hun Suh, Sehyung Cho, Sang Ki Park

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Cdk5 is a kinase involved in the various neuronal processes. Results: Cdk5 directly phosphorylates CLOCK and regulates its transcriptional activity in association with altered stability and subcellular distribution. Conclusion: Cdk5 functions as a regulator of CLOCK protein. Significance: Our findings may provide mechanistic links between diverse Cdk5-mediated brain functions and the molecular clock.

Original languageEnglish
Pages (from-to)36878-36889
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number52
DOIs
Publication statusPublished - 2013 Dec 27

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Kwak, Y., Jeong, J., Lee, S., Park, Y. U., Lee, S. A., Han, D. H., Kim, J. H., Ohshima, T., Mikoshiba, K., Suh, Y. H., Cho, S., & Park, S. K. (2013). Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation. Journal of Biological Chemistry, 288(52), 36878-36889. https://doi.org/10.1074/jbc.M113.494856