Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation

Yongdo Kwak, Jaehoon Jeong, Saebom Lee, Young Un Park, Seol Ae Lee, Dong Hee Han, Joung Hun Kim, Toshio Ohshima, Katsuhiko Mikoshiba, Yoo Hun Suh, Sehyung Cho, Sang Ki Park

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    Background: Cdk5 is a kinase involved in the various neuronal processes. Results: Cdk5 directly phosphorylates CLOCK and regulates its transcriptional activity in association with altered stability and subcellular distribution. Conclusion: Cdk5 functions as a regulator of CLOCK protein. Significance: Our findings may provide mechanistic links between diverse Cdk5-mediated brain functions and the molecular clock.

    Original languageEnglish
    Pages (from-to)36878-36889
    Number of pages12
    JournalJournal of Biological Chemistry
    Volume288
    Issue number52
    DOIs
    Publication statusPublished - 2013 Dec 27

    Fingerprint

    CLOCK Proteins
    Cyclin-Dependent Kinase 5
    Phosphorylation
    Clocks
    Brain
    Phosphotransferases
    Association reactions

    ASJC Scopus subject areas

    • Biochemistry
    • Cell Biology
    • Molecular Biology

    Cite this

    Kwak, Y., Jeong, J., Lee, S., Park, Y. U., Lee, S. A., Han, D. H., ... Park, S. K. (2013). Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation. Journal of Biological Chemistry, 288(52), 36878-36889. https://doi.org/10.1074/jbc.M113.494856

    Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation. / Kwak, Yongdo; Jeong, Jaehoon; Lee, Saebom; Park, Young Un; Lee, Seol Ae; Han, Dong Hee; Kim, Joung Hun; Ohshima, Toshio; Mikoshiba, Katsuhiko; Suh, Yoo Hun; Cho, Sehyung; Park, Sang Ki.

    In: Journal of Biological Chemistry, Vol. 288, No. 52, 27.12.2013, p. 36878-36889.

    Research output: Contribution to journalArticle

    Kwak, Y, Jeong, J, Lee, S, Park, YU, Lee, SA, Han, DH, Kim, JH, Ohshima, T, Mikoshiba, K, Suh, YH, Cho, S & Park, SK 2013, 'Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation', Journal of Biological Chemistry, vol. 288, no. 52, pp. 36878-36889. https://doi.org/10.1074/jbc.M113.494856
    Kwak, Yongdo ; Jeong, Jaehoon ; Lee, Saebom ; Park, Young Un ; Lee, Seol Ae ; Han, Dong Hee ; Kim, Joung Hun ; Ohshima, Toshio ; Mikoshiba, Katsuhiko ; Suh, Yoo Hun ; Cho, Sehyung ; Park, Sang Ki. / Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 52. pp. 36878-36889.
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    AU - Lee, Seol Ae

    AU - Han, Dong Hee

    AU - Kim, Joung Hun

    AU - Ohshima, Toshio

    AU - Mikoshiba, Katsuhiko

    AU - Suh, Yoo Hun

    AU - Cho, Sehyung

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