Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation

Yongdo Kwak; Jaehoon Jeong; Saebom Lee; Young Un Park; Seol Ae Lee; Dong Hee Han; Joung Hun Kim; Toshio Ohshima; Katsuhiko Mikoshiba; Yoo Hun Suh; Sehyung Cho; Sang Ki Park

doi:10.1074/jbc.M113.494856

Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation

Yongdo Kwak, Jaehoon Jeong, Saebom Lee, Young Un Park, Seol Ae Lee, Dong Hee Han, Joung Hun Kim, Toshio Ohshima, Katsuhiko Mikoshiba, Yoo Hun Suh, Sehyung Cho, Sang Ki Park^*

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Background: Cdk5 is a kinase involved in the various neuronal processes. Results: Cdk5 directly phosphorylates CLOCK and regulates its transcriptional activity in association with altered stability and subcellular distribution. Conclusion: Cdk5 functions as a regulator of CLOCK protein. Significance: Our findings may provide mechanistic links between diverse Cdk5-mediated brain functions and the molecular clock.

Original language	English
Pages (from-to)	36878-36889
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	52
DOIs	https://doi.org/10.1074/jbc.M113.494856
Publication status	Published - 2013 Dec 27

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation",

abstract = "Background: Cdk5 is a kinase involved in the various neuronal processes. Results: Cdk5 directly phosphorylates CLOCK and regulates its transcriptional activity in association with altered stability and subcellular distribution. Conclusion: Cdk5 functions as a regulator of CLOCK protein. Significance: Our findings may provide mechanistic links between diverse Cdk5-mediated brain functions and the molecular clock.",

author = "Yongdo Kwak and Jaehoon Jeong and Saebom Lee and Park, {Young Un} and Lee, {Seol Ae} and Han, {Dong Hee} and Kim, {Joung Hun} and Toshio Ohshima and Katsuhiko Mikoshiba and Suh, {Yoo Hun} and Sehyung Cho and Park, {Sang Ki}",

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doi = "10.1074/jbc.M113.494856",

language = "English",

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T1 - Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation

AU - Kwak, Yongdo

AU - Jeong, Jaehoon

AU - Lee, Saebom

AU - Park, Young Un

AU - Lee, Seol Ae

AU - Han, Dong Hee

AU - Kim, Joung Hun

AU - Ohshima, Toshio

AU - Mikoshiba, Katsuhiko

AU - Suh, Yoo Hun

AU - Cho, Sehyung

AU - Park, Sang Ki

PY - 2013/12/27

Y1 - 2013/12/27

N2 - Background: Cdk5 is a kinase involved in the various neuronal processes. Results: Cdk5 directly phosphorylates CLOCK and regulates its transcriptional activity in association with altered stability and subcellular distribution. Conclusion: Cdk5 functions as a regulator of CLOCK protein. Significance: Our findings may provide mechanistic links between diverse Cdk5-mediated brain functions and the molecular clock.

AB - Background: Cdk5 is a kinase involved in the various neuronal processes. Results: Cdk5 directly phosphorylates CLOCK and regulates its transcriptional activity in association with altered stability and subcellular distribution. Conclusion: Cdk5 functions as a regulator of CLOCK protein. Significance: Our findings may provide mechanistic links between diverse Cdk5-mediated brain functions and the molecular clock.

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EP - 36889

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 52

ER -

Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation

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ASJC Scopus subject areas

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