Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone

Yuki Hirota, Toshio Ohshima, Naoko Kaneko, Makiko Ikeda, Takuji Iwasato, Ashok B. Kulkarni, Katsuhiko Mikoshiba, Hideyuki Okano, Kazunobu Sawamoto

    Research output: Contribution to journalArticle

    54 Citations (Scopus)

    Abstract

    At the lateral wall of the lateral ventricles in the adult rodent brain, neuroblasts form an extensive network of elongated cell aggregates called chains in the subventricular zone and migrate toward the olfactory bulb. The molecular mechanisms regulating this migration of neuroblasts are essentially unknown. Here, we report a novel role for cyclin-dependent kinase 5 (Cdk5), a neuronal protein kinase, in this process. Using in vitro and in vivo conditional knock-out experiments, we found that Cdk5 deletion impaired the chain formation, speed, directionality, and leading process extension of the neuroblasts in a cell-autonomous manner. These findings suggest that Cdk5 plays an important role in neuroblast migration in the postnatal subventricular zone.

    Original languageEnglish
    Pages (from-to)12829-12838
    Number of pages10
    JournalJournal of Neuroscience
    Volume27
    Issue number47
    DOIs
    Publication statusPublished - 2007 Nov 21

    Fingerprint

    Cyclin-Dependent Kinase 5
    Lateral Ventricles
    Olfactory Bulb
    Protein Kinases
    Rodentia
    Brain

    Keywords

    • Cdk5
    • Migration
    • Neuroblast
    • Postnatal neurogenesis
    • Rostral migratory stream
    • Subventricular zone

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone. / Hirota, Yuki; Ohshima, Toshio; Kaneko, Naoko; Ikeda, Makiko; Iwasato, Takuji; Kulkarni, Ashok B.; Mikoshiba, Katsuhiko; Okano, Hideyuki; Sawamoto, Kazunobu.

    In: Journal of Neuroscience, Vol. 27, No. 47, 21.11.2007, p. 12829-12838.

    Research output: Contribution to journalArticle

    Hirota, Y, Ohshima, T, Kaneko, N, Ikeda, M, Iwasato, T, Kulkarni, AB, Mikoshiba, K, Okano, H & Sawamoto, K 2007, 'Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone', Journal of Neuroscience, vol. 27, no. 47, pp. 12829-12838. https://doi.org/10.1523/JNEUROSCI.1014-07.2007
    Hirota, Yuki ; Ohshima, Toshio ; Kaneko, Naoko ; Ikeda, Makiko ; Iwasato, Takuji ; Kulkarni, Ashok B. ; Mikoshiba, Katsuhiko ; Okano, Hideyuki ; Sawamoto, Kazunobu. / Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone. In: Journal of Neuroscience. 2007 ; Vol. 27, No. 47. pp. 12829-12838.
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    AU - Iwasato, Takuji

    AU - Kulkarni, Ashok B.

    AU - Mikoshiba, Katsuhiko

    AU - Okano, Hideyuki

    AU - Sawamoto, Kazunobu

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