Cyclotheonamides E2 and E3, new potent serine protease inhibitors from the marine sponge of the genus Theonella

Y. Nakao, N. Oku, S. Matsunaga, N. Fusetani

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Abstract

Two new potent serine protease inhibitors, cyclotheonamides E2 (3) and E3 (4), have been isolated from a marine sponge of the genus Theonella. Their structures were determined by interpretation of spectral data and chemical degradation studies. They are closely related to the previously reported cyclotheonamide E, from which they differ in the N-acyl group of the alanyl side chain. Cyclotheonamides E, E2, and E3 were more active against thrombin than against trypsin.

Original languageEnglish
Pages (from-to)667-670
Number of pages4
JournalJournal of Natural Products
Volume61
Issue number5
DOIs
Publication statusPublished - 1998 Jun 18

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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