Abstract
Two new potent serine protease inhibitors, cyclotheonamides E2 (3) and E3 (4), have been isolated from a marine sponge of the genus Theonella. Their structures were determined by interpretation of spectral data and chemical degradation studies. They are closely related to the previously reported cyclotheonamide E, from which they differ in the N-acyl group of the alanyl side chain. Cyclotheonamides E, E2, and E3 were more active against thrombin than against trypsin.
| Original language | English |
|---|---|
| Pages (from-to) | 667-670 |
| Number of pages | 4 |
| Journal | Journal of Natural Products |
| Volume | 61 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1998 Jun 18 |
| Externally published | Yes |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
