Cytologic features based on the expression of E-cadherin and catenins in lung adenocarcinoma

Ko Tsuji, Takashi Hirano, Hiroyuki Shibanuma, Shinya Okada, Norihiko Kawate, Chimori Konaka, Yoshiro Ebihara, Harubumi Kato

Research output: Contribution to journalArticle

3 Citations (Scopus)


OBJECTIVE: To investigate the relationship between E-cadherin-associated cell-to-cell adhesion and cytologic features in preoperative cytologic lung adenocarcinoma specimens. STUDY DESIGN: Evaluation of the relationship between cell-to-cell adhesion, formation of cellular clusters and frequency of single cells in 31 cases of primary lung adenocarcinoma, collected by brush and needle cytology preoperatively. RESULTS: Most cases with remarkable overlapping of cells in compact cellular clusters and a few solitary cells maintained cell-to-cell adhesion. Cellular clusters that had a slight tendency to overlap, a small cell-to-cell adhesion area and a high frequency of solitary cells tended to lack E-cadherin-associated cell-to-cell adhesion. CONCLUSION: Formation of cellular clusters and the appearance of solitary cancer cells are closely related to E-cadherin-associated cell-to-cell adhesion. Therefore, it is highly likely that cytologic features may indicate malignant behavior, such as local invasion and lymph node metastasis, in primary lung adenocarcinoma.

Original languageEnglish
Pages (from-to)381-389
Number of pages9
JournalActa Cytologica
Issue number3
Publication statusPublished - 1999
Externally publishedYes



  • Adenocarcinomas
  • Catenins
  • E-cadherins
  • Lung neoplasms

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology
  • Histology

Cite this

Tsuji, K., Hirano, T., Shibanuma, H., Okada, S., Kawate, N., Konaka, C., Ebihara, Y., & Kato, H. (1999). Cytologic features based on the expression of E-cadherin and catenins in lung adenocarcinoma. Acta Cytologica, 43(3), 381-389.