Cytotoxic C47-polyacetylene carboxylic acids from a marine sponge Pertrosia sp

Chikane Okamoto, Youichi Nakao, Tsuyoshi Fujita, Takashi Iwashita, Rob W M Van Soest, Nobuhiro Fusetani, Shigeki Matsunaga

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Two new polyacetylene carboxylic acids, petroformynic acids B (3) and C (4), were isolated from a marine sponge Pertrosia sp. as cytotoxic constituents. Their structures were determined by interpretation of 2D NMR data and tandem FABMS data. Absolute stereochemistry of 3 was assigned by application of the modified Mosher analysis. Petroformynic acids exhibit moderate cytotoxic activity against P388 cells.

Original languageEnglish
Pages (from-to)1816-1819
Number of pages4
JournalJournal of Natural Products
Volume70
Issue number11
DOIs
Publication statusPublished - 2007 Nov
Externally publishedYes

Fingerprint

Polyacetylenes
polyacetylenes
Stereochemistry
Porifera
carboxylic acids
Carboxylic Acids
Nuclear magnetic resonance
Acids
acids
stereochemistry
cells
petroformynic acid B
petroformynic acid C

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Okamoto, C., Nakao, Y., Fujita, T., Iwashita, T., Van Soest, R. W. M., Fusetani, N., & Matsunaga, S. (2007). Cytotoxic C47-polyacetylene carboxylic acids from a marine sponge Pertrosia sp. Journal of Natural Products, 70(11), 1816-1819. https://doi.org/10.1021/np0702943

Cytotoxic C47-polyacetylene carboxylic acids from a marine sponge Pertrosia sp. / Okamoto, Chikane; Nakao, Youichi; Fujita, Tsuyoshi; Iwashita, Takashi; Van Soest, Rob W M; Fusetani, Nobuhiro; Matsunaga, Shigeki.

In: Journal of Natural Products, Vol. 70, No. 11, 11.2007, p. 1816-1819.

Research output: Contribution to journalArticle

Okamoto, C, Nakao, Y, Fujita, T, Iwashita, T, Van Soest, RWM, Fusetani, N & Matsunaga, S 2007, 'Cytotoxic C47-polyacetylene carboxylic acids from a marine sponge Pertrosia sp', Journal of Natural Products, vol. 70, no. 11, pp. 1816-1819. https://doi.org/10.1021/np0702943
Okamoto, Chikane ; Nakao, Youichi ; Fujita, Tsuyoshi ; Iwashita, Takashi ; Van Soest, Rob W M ; Fusetani, Nobuhiro ; Matsunaga, Shigeki. / Cytotoxic C47-polyacetylene carboxylic acids from a marine sponge Pertrosia sp. In: Journal of Natural Products. 2007 ; Vol. 70, No. 11. pp. 1816-1819.
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