Cytotoxic C47-polyacetylene carboxylic acids from a marine sponge Pertrosia sp

Chikane Okamoto, Yoichi Nakao, Tsuyoshi Fujita, Takashi Iwashita, Rob W.M. Van Soest, Nobuhiro Fusetani, Shigeki Matsunaga

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15 Citations (Scopus)

Abstract

Two new polyacetylene carboxylic acids, petroformynic acids B (3) and C (4), were isolated from a marine sponge Pertrosia sp. as cytotoxic constituents. Their structures were determined by interpretation of 2D NMR data and tandem FABMS data. Absolute stereochemistry of 3 was assigned by application of the modified Mosher analysis. Petroformynic acids exhibit moderate cytotoxic activity against P388 cells.

Original languageEnglish
Pages (from-to)1816-1819
Number of pages4
JournalJournal of Natural Products
Volume70
Issue number11
DOIs
Publication statusPublished - 2007 Nov

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Okamoto, C., Nakao, Y., Fujita, T., Iwashita, T., Van Soest, R. W. M., Fusetani, N., & Matsunaga, S. (2007). Cytotoxic C47-polyacetylene carboxylic acids from a marine sponge Pertrosia sp. Journal of Natural Products, 70(11), 1816-1819. https://doi.org/10.1021/np0702943