Cytotoxicity of synthetic barium hydroxyapatite

Masanori Kikuchi, Atsushi Yamazaki, Masaru Akao, Hideki Aoki

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    Barium hydroxyapatite (Ba10(PO4)6(OH)2, Ba-HAp) was synthesized by a wet method using Ba(OH)2 · 8H2O and (NH4)2HPO4 as starting materials. The Ba-HAp obtained had a Ba/P atomic ratio of 1.76 and contained CO3 groups. The Ba-HAp was sintered at 1073 K for 12 hours. The sintered Ba-HAp had a three point bending strength of 29 MPa and Young's modulus of 27 GPa. Cytotoxicity of the sintered bodies and particles was tested using L-cells. The sintered Ba-HAp showed no cytotoxicity, and the cells were closely in contact with the surfaces of sintered Ba-HAp. Morphological observation of the cell around the Ba-HAp particles also showed no cytotoxicity. However, cell growth was inhibited by Ca adsorption on the Ba-HAp particles. These results suggested that the Ba-HAp had no cytotoxicity and can be applied as a bioactive X-ray opaque material.

    Original languageEnglish
    Pages (from-to)405-413
    Number of pages9
    JournalBio-Medical Materials and Engineering
    Volume6
    Issue number6
    Publication statusPublished - 1996

    Fingerprint

    Cytotoxicity
    Barium
    Hydroxyapatite
    Elastic Modulus
    Cell growth
    Bending strength
    Adsorption
    Elastic moduli
    Observation
    X-Rays
    X rays
    barium hydroxyapatite
    Growth

    Keywords

    • Barium hydroxyapatite
    • Ca adsorption
    • Cell growth inhibition
    • Cytotoxicity
    • Mechanical strength

    ASJC Scopus subject areas

    • Biophysics

    Cite this

    Cytotoxicity of synthetic barium hydroxyapatite. / Kikuchi, Masanori; Yamazaki, Atsushi; Akao, Masaru; Aoki, Hideki.

    In: Bio-Medical Materials and Engineering, Vol. 6, No. 6, 1996, p. 405-413.

    Research output: Contribution to journalArticle

    Kikuchi, M, Yamazaki, A, Akao, M & Aoki, H 1996, 'Cytotoxicity of synthetic barium hydroxyapatite', Bio-Medical Materials and Engineering, vol. 6, no. 6, pp. 405-413.
    Kikuchi, Masanori ; Yamazaki, Atsushi ; Akao, Masaru ; Aoki, Hideki. / Cytotoxicity of synthetic barium hydroxyapatite. In: Bio-Medical Materials and Engineering. 1996 ; Vol. 6, No. 6. pp. 405-413.
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