Daily behavioral and sleep patterns are associated with aging-induced male-specific disorders in individuals with reduced renal function

Masaki Yoshioka, Keisei Kosaki, Shunta Noma, Masahiro Matsui, Makoto Kuro-o, Ai Shibata, Chie Saito, Kunihiro Yamagata, Koichiro Oka, Seiji Maeda*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The development of aging-induced male-specific disorders is accelerated by impaired renal function. Although aging-induced male-specific disorders are clinically serious complications in individuals with reduced renal function, their practical management strategies remain obscure. The purpose of this cross-sectional study was to investigate the association between daily behavioral and sleep patterns and aging-induced male-specific disorders in individuals with reduced renal function. Methods: Eighty men with glomerular filtration rate stage 2–4 (age, 67 ± 9 years), sedentary behavior and physical activity were assessed using a triaxial accelerometer. The mean sleep time was calculated from the sleep time during the accelerometer measurement. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Aging-induced male-specific disorders were assessed using the Aging Males’ Symptoms Questionnaire (AMS). Results: A lower moderate to vigorous-intensity physical activity (MVPA) time and a higher PSQI score were independently associated with a higher AMS score. Moreover, when the participants were divided into four groups according to the median MVPA values and the PSQI score (more or less than 6 points), the AMS score was the highest in those with a lower MVPA time and a higher PSQI score. In the mediation analysis, the PSQI score did not mediate a correlation between the MVPA time and AMS score. MVPA time also did not mediate a correlation between the PSQI and AMS scores. Conclusions: Collectively, these findings suggest that increasing MVPA time and improving sleep quality may contribute to attenuating aging-induced male-specific disorders in individuals with reduced renal function.

Original languageEnglish
Article number111717
JournalExperimental Gerontology
Volume161
DOIs
Publication statusPublished - 2022 May

Keywords

  • Aging Males’ Symptoms
  • Male sexual function
  • Physical activity
  • Renal impairment
  • Sleep quality

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Daily behavioral and sleep patterns are associated with aging-induced male-specific disorders in individuals with reduced renal function'. Together they form a unique fingerprint.

Cite this