Daily injection of insulin attenuated impairment of liver circadian clock oscillation in the streptozotocin-treated diabetic mouse

Koji Kuriyama, Kei Sasahara, Takashi Kudo, Shigenobu Shibata

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Recent studies have shown a dampened amplitude of clock gene rhythm in the heart and liver of streptozotocin (STZ)-treated rats and mice, however it is unknown whether impairment is due to dysfunction of the suprachiasmatic nucleus (SCN) or not. Rhythmic expression of mPER2 was dampened in the STZ-treated mouse liver but not SCN and cerebral cortex. Injection of insulin could normalize an impairment of mPer2 and mPER2 expression rhythm in the liver, when it was injected at nighttime, but not at daytime. In the present study, we demonstrated that insulin-dependent diabetes impaired oscillation of the peripheral clock gene and its product. Insulin injection can recover dampened oscillation of the peripheral clock depending on its injection time.

Original languageEnglish
Pages (from-to)206-210
Number of pages5
JournalFEBS Letters
Volume572
Issue number1-3
DOIs
Publication statusPublished - 2004 Aug 13

Keywords

  • Circadian
  • Clock gene
  • LD, light-dark
  • Restricted feeding
  • SCN, suprachiasmatic nucleus
  • STZ, streptozotocin
  • Streptozotocin
  • ZT, Zeitgeber time
  • db/db

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint Dive into the research topics of 'Daily injection of insulin attenuated impairment of liver circadian clock oscillation in the streptozotocin-treated diabetic mouse'. Together they form a unique fingerprint.

  • Cite this