Daily injection of insulin attenuated impairment of liver circadian clock oscillation in the streptozotocin-treated diabetic mouse

Koji Kuriyama, Kei Sasahara, Takashi Kudo, Shigenobu Shibata

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    37 Citations (Scopus)


    Recent studies have shown a dampened amplitude of clock gene rhythm in the heart and liver of streptozotocin (STZ)-treated rats and mice, however it is unknown whether impairment is due to dysfunction of the suprachiasmatic nucleus (SCN) or not. Rhythmic expression of mPER2 was dampened in the STZ-treated mouse liver but not SCN and cerebral cortex. Injection of insulin could normalize an impairment of mPer2 and mPER2 expression rhythm in the liver, when it was injected at nighttime, but not at daytime. In the present study, we demonstrated that insulin-dependent diabetes impaired oscillation of the peripheral clock gene and its product. Insulin injection can recover dampened oscillation of the peripheral clock depending on its injection time.

    Original languageEnglish
    Pages (from-to)206-210
    Number of pages5
    JournalFEBS Letters
    Issue number1-3
    Publication statusPublished - 2004 Aug 13



    • Circadian
    • Clock gene
    • db/db
    • LD, light-dark
    • Restricted feeding
    • SCN, suprachiasmatic nucleus
    • Streptozotocin
    • STZ, streptozotocin
    • ZT, Zeitgeber time

    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Molecular Biology

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