This paper describes the high-cycle fatigue characteristics of quasi-isotropic CFRP laminates [-45/0/45/90] s up to 10 8 cycles. To investigate the fatigue behavior in the high-life region, the fatigue tests were conducted with the frequency of 100Hz since it's difficult to conduct the tests with 5Hz. Then, the damage behavior of the specimen was observed with a microscope, a soft X-ray photography and a 3D ultrasonic inspection system. In this study, to evaluate quantitative characteristics of each the transverse crack propagation and the delamination growth in the high-cycle region, the energy release rate associated with damage growth to the width direction was calculate. The transverse crack propagation and the delamination growth to the width direction were evaluated based on a modified Paris-law approach. As the results, it was found that transverse crack propagation didn't depend on the frequency within the small temperature change and it was observed that delamination growth delayed with the test condition of less than σ max/σ b=0.3 of the applied stress level.