Decarbonylative Diaryl Ether Synthesis by Pd and Ni Catalysis

Ryosuke Takise, Ryota Isshiki, Kei Muto, Kenichiro Itami*, Junichiro Yamaguchi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

85 Citations (Scopus)

Abstract

Because diaryl ethers are present as an important motif in pharmaceuticals and natural products, extensive studies for the development of novel methods have been conducted. A conventional method for the construction of the diaryl ether moiety is the intermolecular cross-coupling reaction of aryl halides and phenols with a copper or palladium catalyst. We developed a catalytic decarbonylative etherification of aromatic esters using a palladium or nickel catalyst with our enabling diphosphine ligand to give the corresponding diaryl ethers. The present reaction can be conducted on gram scale in excellent yield. This reaction not only functions in an intramolecular setting but also allows for a cross-etherification using other phenols.

Original languageEnglish
Pages (from-to)3340-3343
Number of pages4
JournalJournal of the American Chemical Society
Volume139
Issue number9
DOIs
Publication statusPublished - 2017 Mar 8

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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