Decarbonylative Methylation of Aromatic Esters by a Nickel Catalyst

Toshimasa Okita, Kei Muto, Junichiro Yamaguchi

    Research output: Contribution to journal › Article

    4 Citations (Scopus)

    Abstract

    A Ni-catalyzed decarbonylative methylation of aromatic esters was achieved using methylaluminums as methylating agents. Dimethylaluminum chlorides uniquely worked as the methyl source. Because of the Lewis acidity of aluminum reagents, less reactive alkyl esters could also undergo the present methylation. By controlling the Lewis acidity of aluminum reagents, a chemoselective decarbonylative cross-coupling between alkyl esters and phenyl esters was successful.

    Original languageEnglish
    Pages (from-to)3132-3135
    Number of pages4
    JournalOrganic Letters
    Volume20
    Issue number10
    DOIs
    Publication statusPublished - 2018 May 18

    Fingerprint

    methylation
    Methylation
    Nickel
    esters
    Esters
    nickel
    catalysts
    Catalysts
    Aluminum
    Acidity
    acidity
    reagents
    aluminum
    cross coupling
    chlorides

    ASJC Scopus subject areas

    • Biochemistry
    • Physical and Theoretical Chemistry
    • Organic Chemistry

    Cite this

    Decarbonylative Methylation of Aromatic Esters by a Nickel Catalyst. / Okita, Toshimasa; Muto, Kei; Yamaguchi, Junichiro.

    In: Organic Letters, Vol. 20, No. 10, 18.05.2018, p. 3132-3135.

    Research output: Contribution to journal › Article

    Okita, T, Muto, K & Yamaguchi, J 2018, 'Decarbonylative Methylation of Aromatic Esters by a Nickel Catalyst', Organic Letters, vol. 20, no. 10, pp. 3132-3135. https://doi.org/10.1021/acs.orglett.8b01233
    Okita T, Muto K, Yamaguchi J. Decarbonylative Methylation of Aromatic Esters by a Nickel Catalyst. Organic Letters. 2018 May 18;20(10):3132-3135. https://doi.org/10.1021/acs.orglett.8b01233
    Okita, Toshimasa ; Muto, Kei ; Yamaguchi, Junichiro. / Decarbonylative Methylation of Aromatic Esters by a Nickel Catalyst. In: Organic Letters. 2018 ; Vol. 20, No. 10. pp. 3132-3135.
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