Decarbonylative Methylation of Aromatic Esters by a Nickel Catalyst

Toshimasa Okita, Kei Muto, Junichiro Yamaguchi

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    A Ni-catalyzed decarbonylative methylation of aromatic esters was achieved using methylaluminums as methylating agents. Dimethylaluminum chlorides uniquely worked as the methyl source. Because of the Lewis acidity of aluminum reagents, less reactive alkyl esters could also undergo the present methylation. By controlling the Lewis acidity of aluminum reagents, a chemoselective decarbonylative cross-coupling between alkyl esters and phenyl esters was successful.

    Original languageEnglish
    Pages (from-to)3132-3135
    Number of pages4
    JournalOrganic Letters
    Volume20
    Issue number10
    DOIs
    Publication statusPublished - 2018 May 18

    ASJC Scopus subject areas

    • Biochemistry
    • Physical and Theoretical Chemistry
    • Organic Chemistry

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