Abstract
A Ni-catalyzed decarbonylative methylation of aromatic esters was achieved using methylaluminums as methylating agents. Dimethylaluminum chlorides uniquely worked as the methyl source. Because of the Lewis acidity of aluminum reagents, less reactive alkyl esters could also undergo the present methylation. By controlling the Lewis acidity of aluminum reagents, a chemoselective decarbonylative cross-coupling between alkyl esters and phenyl esters was successful.
| Original language | English |
|---|---|
| Pages (from-to) | 3132-3135 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 20 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2018 May 18 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Cite this
Okita, T., Muto, K., & Yamaguchi, J. (2018). Decarbonylative Methylation of Aromatic Esters by a Nickel Catalyst. Organic Letters, 20(10), 3132-3135. https://doi.org/10.1021/acs.orglett.8b01233