Abstract
A Ni-catalyzed decarbonylative methylation of aromatic esters was achieved using methylaluminums as methylating agents. Dimethylaluminum chlorides uniquely worked as the methyl source. Because of the Lewis acidity of aluminum reagents, less reactive alkyl esters could also undergo the present methylation. By controlling the Lewis acidity of aluminum reagents, a chemoselective decarbonylative cross-coupling between alkyl esters and phenyl esters was successful.
| Original language | English |
|---|---|
| Pages (from-to) | 3132-3135 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 20 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2018 May 18 |
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ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
Cite this
Decarbonylative Methylation of Aromatic Esters by a Nickel Catalyst. / Okita, Toshimasa; Muto, Kei; Yamaguchi, Junichiro.
In: Organic Letters, Vol. 20, No. 10, 18.05.2018, p. 3132-3135.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Decarbonylative Methylation of Aromatic Esters by a Nickel Catalyst
AU - Okita, Toshimasa
AU - Muto, Kei
AU - Yamaguchi, Junichiro
PY - 2018/5/18
Y1 - 2018/5/18
N2 - A Ni-catalyzed decarbonylative methylation of aromatic esters was achieved using methylaluminums as methylating agents. Dimethylaluminum chlorides uniquely worked as the methyl source. Because of the Lewis acidity of aluminum reagents, less reactive alkyl esters could also undergo the present methylation. By controlling the Lewis acidity of aluminum reagents, a chemoselective decarbonylative cross-coupling between alkyl esters and phenyl esters was successful.
AB - A Ni-catalyzed decarbonylative methylation of aromatic esters was achieved using methylaluminums as methylating agents. Dimethylaluminum chlorides uniquely worked as the methyl source. Because of the Lewis acidity of aluminum reagents, less reactive alkyl esters could also undergo the present methylation. By controlling the Lewis acidity of aluminum reagents, a chemoselective decarbonylative cross-coupling between alkyl esters and phenyl esters was successful.
UR - http://www.scopus.com/inward/record.url?scp=85047345740&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047345740&partnerID=8YFLogxK
U2 - 10.1021/acs.orglett.8b01233
DO - 10.1021/acs.orglett.8b01233
M3 - Article
AN - SCOPUS:85047345740
VL - 20
SP - 3132
EP - 3135
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 10
ER -