Decarbonylative Synthesis of Aryl Nitriles from Aromatic Esters and Organocyanides by a Nickel Catalyst

Keiichiro Iizumi, Miki B. Kurosawa, Ryota Isshiki, Kei Muto, Junichiro Yamaguchi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

A decarbonylative cyanation of aromatic esters with aminoacetonitriles in the presence of a nickel catalyst was developed. The key to this reaction was the use of a thiophene-based diphosphine ligand, dcypt, permitting the synthesis of aryl nitrile without the generation of stoichiometric metal- or halogen-containing chemical wastes. A wide range of aromatic esters, including hetarenes and pharmaceutical molecules, can be converted into aryl nitriles.

Original languageEnglish
Article numberst-2020-k0464-c
Pages (from-to)1555-1559
Number of pages5
JournalSynlett
Volume32
Issue number15
DOIs
Publication statusPublished - 2021 Sep 16

Keywords

  • aminoacetonitriles
  • aromatic esters
  • coupling reaction
  • cyanation
  • nickel catalysis

ASJC Scopus subject areas

  • Organic Chemistry

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