Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae

Yoshihiro Watanabe, Takuya Suga, Satomi Narusawa, Masato Iwatsuki, Kenichi Nonaka, Takuji Nakashima, Yasuo Shinohara, Takahiro Shiotsuki, Naoya Ichimaru, Hideto Miyoshi, Yukihiro Asami, Satoshi Omura, Kazuro Shiomi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

A new decalin, decatamariic acid, was isolated from a cultured broth of the fungus Aspergillus tamarii FKI-6817. Its absolute configuration was elucidated by NMR and electronic circular dichroism. Decatamariic acid (10 μM) elicited ∼50% inhibition of the ATP production in mitochondria isolated from wild-type Saccharomyces cerevisiae without affecting the activities of respiratory enzymes. The action manner of this compound may be interesting as a possible seed for new pesticides.

Original languageEnglish
Pages (from-to)395-399
Number of pages5
JournalJournal of Antibiotics
Volume70
Issue number4
DOIs
Publication statusPublished - 2017 Apr 1
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Fingerprint

Dive into the research topics of 'Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae'. Together they form a unique fingerprint.

Cite this