Decrease of sexual receptivity by prolylendopeptidase inhibitor in female rats

Izumi Oosuka, Yoshiaki Tanaka, Naoyoshi Miura, Korehito Yamanouchi

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1 Citation (Scopus)


The effects of a prolylendopeptidase inhibitor, 1-[3-(2-indanylanylacetyl)-L-thioprolyl]pyrrolidine (Z-321), on lordosis behavior were investigated in estrogen and progesterone-treated ovariectomized rats. Females were orally administered 100, 200 or 300 mg/kg Z-321 or the vehicle (control). The mean lordosis quotient in the rats given 300 mg/kg Z-321 was lower than that in control group, but that in rats given 100 or 200 mg/kg Z-321 was not lower. Thus, Z-321 suppressed lordosis in estrogen and progesterone-treated ovariectomized rats. Peptide neurotransmitters, especially those containing proline, are thought to be involved in the inhibitory mechanisms for lordosis behavior.

Original languageEnglish
Pages (from-to)82-85
Number of pages4
JournalJapanese Journal of Pharmacology
Issue number1
Publication statusPublished - 2000



  • Lordosis
  • Peptide neurotransmitter
  • Prolylendopeptidase inhibitor

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

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