Decrease of sexual receptivity by prolylendopeptidase inhibitor in female rats

Izumi Oosuka, Yoshiaki Tanaka, Naoyoshi Miura, Korehito Yamanouchi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effects of a prolylendopeptidase inhibitor, 1-[3-(2-indanylanylacetyl)-L-thioprolyl]pyrrolidine (Z-321), on lordosis behavior were investigated in estrogen and progesterone-treated ovariectomized rats. Females were orally administered 100, 200 or 300 mg/kg Z-321 or the vehicle (control). The mean lordosis quotient in the rats given 300 mg/kg Z-321 was lower than that in control group, but that in rats given 100 or 200 mg/kg Z-321 was not lower. Thus, Z-321 suppressed lordosis in estrogen and progesterone-treated ovariectomized rats. Peptide neurotransmitters, especially those containing proline, are thought to be involved in the inhibitory mechanisms for lordosis behavior.

Original languageEnglish
Pages (from-to)82-85
Number of pages4
JournalJapanese Journal of Pharmacology
Volume83
Issue number1
DOIs
Publication statusPublished - 2000

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Lordosis
Progesterone
Estrogens
Proline
Neurotransmitter Agents
1-(3-(2-indanylacetyl)-L-thioprolyl)pyrrolidine
Control Groups
Peptides

Keywords

  • Lordosis
  • Peptide neurotransmitter
  • Prolylendopeptidase inhibitor

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Decrease of sexual receptivity by prolylendopeptidase inhibitor in female rats. / Oosuka, Izumi; Tanaka, Yoshiaki; Miura, Naoyoshi; Yamanouchi, Korehito.

In: Japanese Journal of Pharmacology, Vol. 83, No. 1, 2000, p. 82-85.

Research output: Contribution to journalArticle

Oosuka, Izumi ; Tanaka, Yoshiaki ; Miura, Naoyoshi ; Yamanouchi, Korehito. / Decrease of sexual receptivity by prolylendopeptidase inhibitor in female rats. In: Japanese Journal of Pharmacology. 2000 ; Vol. 83, No. 1. pp. 82-85.
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