Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats

Shiro Yamanouchi, Takao Shimazoe, Seiko Nagata, Takahiro Moriya, Miyuki Maetani, Shigenobu Shibata, Shigenori Watanabe, Kyoko Miyasaka, Akira Kono, Akihiro Funakoshi

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).

    Original languageEnglish
    Pages (from-to)103-106
    Number of pages4
    JournalNeuroscience Letters
    Volume227
    Issue number2
    DOIs
    Publication statusPublished - 1997 May 16

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    Suprachiasmatic Nucleus
    Inbred OLETF Rats
    Streptozocin
    Light
    Wistar Rats

    Keywords

    • Circadian rhythm
    • Diabetes
    • Fos
    • Otsuka Long-Evans Tokushima Fatty rats
    • Streptozotocin
    • Suprachiasmatic nucleus

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats. / Yamanouchi, Shiro; Shimazoe, Takao; Nagata, Seiko; Moriya, Takahiro; Maetani, Miyuki; Shibata, Shigenobu; Watanabe, Shigenori; Miyasaka, Kyoko; Kono, Akira; Funakoshi, Akihiro.

    In: Neuroscience Letters, Vol. 227, No. 2, 16.05.1997, p. 103-106.

    Research output: Contribution to journalArticle

    Yamanouchi, S, Shimazoe, T, Nagata, S, Moriya, T, Maetani, M, Shibata, S, Watanabe, S, Miyasaka, K, Kono, A & Funakoshi, A 1997, 'Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats', Neuroscience Letters, vol. 227, no. 2, pp. 103-106. https://doi.org/10.1016/S0304-3940(97)00324-8
    Yamanouchi, Shiro ; Shimazoe, Takao ; Nagata, Seiko ; Moriya, Takahiro ; Maetani, Miyuki ; Shibata, Shigenobu ; Watanabe, Shigenori ; Miyasaka, Kyoko ; Kono, Akira ; Funakoshi, Akihiro. / Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats. In: Neuroscience Letters. 1997 ; Vol. 227, No. 2. pp. 103-106.
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