Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats

Shiro Yamanouchi; Takao Shimazoe; Seiko Nagata; Takahiro Moriya; Miyuki Maetani; Shigenobu Shibata; Shigenori Watanabe; Kyoko Miyasaka; Akira Kono; Akihiro Funakoshi

doi:10.1016/S0304-3940(97)00324-8

Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats

Shiro Yamanouchi, Takao Shimazoe^*, Seiko Nagata, Takahiro Moriya, Miyuki Maetani, Shigenobu Shibata, Shigenori Watanabe, Kyoko Miyasaka, Akira Kono, Akihiro Funakoshi

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).

Original language	English
Pages (from-to)	103-106
Number of pages	4
Journal	Neuroscience Letters
Volume	227
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(97)00324-8
Publication status	Published - 1997 May 16

Keywords

Circadian rhythm
Diabetes
Fos
Otsuka Long-Evans Tokushima Fatty rats
Streptozotocin
Suprachiasmatic nucleus

ASJC Scopus subject areas

Neuroscience(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3940(97)00324-8

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title = "Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats",

abstract = "We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).",

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author = "Shiro Yamanouchi and Takao Shimazoe and Seiko Nagata and Takahiro Moriya and Miyuki Maetani and Shigenobu Shibata and Shigenori Watanabe and Kyoko Miyasaka and Akira Kono and Akihiro Funakoshi",

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doi = "10.1016/S0304-3940(97)00324-8",

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AU - Yamanouchi, Shiro

AU - Shimazoe, Takao

AU - Nagata, Seiko

AU - Moriya, Takahiro

AU - Maetani, Miyuki

AU - Shibata, Shigenobu

AU - Watanabe, Shigenori

AU - Miyasaka, Kyoko

AU - Kono, Akira

AU - Funakoshi, Akihiro

PY - 1997/5/16

Y1 - 1997/5/16

N2 - We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).

AB - We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).

KW - Circadian rhythm

KW - Diabetes

KW - Fos

KW - Otsuka Long-Evans Tokushima Fatty rats

KW - Streptozotocin

KW - Suprachiasmatic nucleus

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ER -

Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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