Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats

Shiro Yamanouchi, Takao Shimazoe, Seiko Nagata, Takahiro Moriya, Miyuki Maetani, Shigenobu Shibata, Shigenori Watanabe, Kyoko Miyasaka, Akira Kono, Akihiro Funakoshi

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Abstract

We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalNeuroscience Letters
Volume227
Issue number2
DOIs
Publication statusPublished - 1997 May 16

Keywords

  • Circadian rhythm
  • Diabetes
  • Fos
  • Otsuka Long-Evans Tokushima Fatty rats
  • Streptozotocin
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

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    Yamanouchi, S., Shimazoe, T., Nagata, S., Moriya, T., Maetani, M., Shibata, S., Watanabe, S., Miyasaka, K., Kono, A., & Funakoshi, A. (1997). Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats. Neuroscience Letters, 227(2), 103-106. https://doi.org/10.1016/S0304-3940(97)00324-8