Decreased response inhibition in middle-aged male patients with type 2 diabetes

Kaya T. Ishizawa, Hiroaki Kumano, Atsushi Sato, Hiroshi Sakura, Yasuhiko Iwamoto

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Background: This study was performed to examine whether patients with type 2 diabetes have cognitive deficits associated with the prefrontal cortex (PFC).Methods: Twenty-seven middle-aged patients with newly diagnosed type 2 diabetes and 27 healthy controls underwent physical measurements and neuropsychological tasks. Response inhibition, reward prediction, and executive function were assessed by the Go/NoGo task, the reversal and extinction tasks, and the Wisconsin Card Sorting Test (WCST). To examine the interactions of being overweight with diabetes on cognitive performance, performance data were analysed by two-way ANCOVA with diabetes and overweight as factors and age as a covariate.Results: Patients with type 2 diabetes showed significantly decreased response inhibition in the Go/NoGo task (discriminability index: P = 0.001). There was an interaction of being overweight with diabetes on reaction time in the Go trials of the Go/NoGo task (P = 0.009). Being overweight was related to retained responses to the presentiment of reward in the extinction task (P = 0.029). The four groups showed normal cognitive performance in the WCST.Conclusions: Our results showed that middle-aged, newly diagnosed and medication-free patients with type 2 diabetes have a particular neuropsychological deficit in inhibitory control of impulsive response, which is an independent effect of diabetes apart from being overweight.

    Original languageEnglish
    Article number1
    JournalBioPsychoSocial Medicine
    Volume4
    DOIs
    Publication statusPublished - 2010 Feb 11

    Fingerprint

    Type 2 Diabetes Mellitus
    Reward
    Age Factors
    Executive Function
    Prefrontal Cortex
    Reaction Time
    Inhibition (Psychology)
    Psychological Extinction

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Biological Psychiatry
    • Psychology(all)
    • Social Psychology

    Cite this

    Decreased response inhibition in middle-aged male patients with type 2 diabetes. / Ishizawa, Kaya T.; Kumano, Hiroaki; Sato, Atsushi; Sakura, Hiroshi; Iwamoto, Yasuhiko.

    In: BioPsychoSocial Medicine, Vol. 4, 1, 11.02.2010.

    Research output: Contribution to journalArticle

    Ishizawa, Kaya T. ; Kumano, Hiroaki ; Sato, Atsushi ; Sakura, Hiroshi ; Iwamoto, Yasuhiko. / Decreased response inhibition in middle-aged male patients with type 2 diabetes. In: BioPsychoSocial Medicine. 2010 ; Vol. 4.
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    AU - Sato, Atsushi

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